Linked Life Data

8119031

Source:http://linkedlifedata.com/resource/pubmed/id/8119031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
299
pubmed:dateCreated
1994-4-7
pubmed:abstractText
Experimental osteoarthrosis of the knee joint was induced in rabbits using a polyethylene binding brace. A 1% solution of sodium hyaluronate (HA) of molecular weight 1.73 x 10(6) (HA-173) was administered intraarticularly at a dosage of 0.1 ml/kg body weight twice a week. Changes in articular cartilage and synovial membrane, and joint contracture were compared with a saline control group at intervals throughout a six-week period of immobilization. In all groups, articular cartilage degeneration and joint contracture progressed with time but were inhibited by the administration of HA-173. Additionally, the results of a 1% solution of HA of molecular weight 9.8 x 10(5) (HA-98), a 1% solution of HA of molecular weight 2.02 x 10(6) (HA-202), and saline, each administered twice a week for five weeks at a dose of 0.1 ml/kg body weight, were compared. It was clear that the articular cartilage degeneration was significantly inhibited by HA as compared with saline, and that the effect was more potent with the higher molecular weight, HA-202, than with HA-98. Furthermore, joint contracture was inhibited by HA, and the effect was more potent with the higher molecular weight, HA-202, than with HA-98.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
282-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effect of high-molecular-weight sodium hyaluronate on immobilized rabbit knee.
pubmed:affiliation
Department of Orthopaedic Surgery, Tokyo Kouseinenkin Hospital, Japan.
pubmed:publicationType
Journal Article, Comparative Study