Linked Life Data

8118887

Source:http://linkedlifedata.com/resource/pubmed/id/8118887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-4-6
pubmed:abstractText
All CD8+ T cell clones used in this study secreted IL-10, and their proliferation was inhibited by exogenous IL-10. This study addresses the question of whether IL-10 produced by responding T cell clones would inhibit proliferation of the secreting T cells themselves. Anti-IL-10 antibodies enhanced the proliferative response of the CD8+ T cell clones, the enhancing effect appearing in the late period of proliferation. However, the proliferation of both CD4+ Th1 and Th2 clones was not affected by anti-IL-10 throughout the culture. In addition to that of the cloned T cells, the proliferative response of a primary culture of CD8+ T cells was enhanced by the anti-IL-10 antibody. This is the first report on a lymphokine which has an autoregulatory role in inhibiting T cell proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-201
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Anti-IL-10 antibody enhances the proliferation of CD8+ T cell clones: autoregulatory role of murine IL-10 in CD8+ T cells.
pubmed:affiliation
Department of Agricultural Chemistry, University of Tokyo, Japan.
pubmed:publicationType
Journal Article