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| pubmed-article:8118884 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:8118884 | lifeskim:mentions | umls-concept:C1416894 | lld:lifeskim |
| pubmed-article:8118884 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:8118884 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8118884 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:8118884 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:8118884 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8118884 | pubmed:dateCreated | 1994-4-6 | lld:pubmed |
| pubmed-article:8118884 | pubmed:abstractText | Spontaneous resorption (abortion) that occurs at a high rate in DBA/2-mated CBA/J female mice is dependent upon asialoGM1+ natural effector-type cells, can be ameliorated by alloimmunization or administration of GM-CSF, and is augmented by in vivo injection of anti-CD8 antibody. The abortion rate was similarly augmented by administration of monoclonal anti-GM-CSF neutralizing antibody, but the GM-CSF physiologically active in preventing abortion during normal pregnancy did not appear to be derived from maternal CB8+ T cells putatively responding to antigens on the fetoplacental unit. Rather, depletion of CD8+ cells in vivo prevented GM-CSF from reducing the rate of resorptions. GM-CSF administration rapidly downregulates natural effector cells able to kill a trophoblast target cell line in vitro, and anti-CD8+ antibody boosts total splenic cytotoxic cell activity. Further, anti-CD8 completely abrogated the ability of GM-CSF to suppress anti-trophoblast killer cell activity. These cells are known to be asialoGM1+ and injection of anti-asialoGM1 reduced the abortion rate appropriately in mice that had received anti-CD8. These data suggest that GM-CSF acts indirectly to prevent abortion in DBA/2-mated CBA/J mice through a mechanism that requires CD8+ maternal T cells, and systemic regulation of the level of anti-trophoblast killer cell activity may determine the success or failure of pregnancy in this system. | lld:pubmed |
| pubmed-article:8118884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8118884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8118884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8118884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8118884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8118884 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8118884 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:8118884 | pubmed:author | pubmed-author:ClarkD ADA | lld:pubmed |
| pubmed-article:8118884 | pubmed:author | pubmed-author:WegmannT GTG | lld:pubmed |
| pubmed-article:8118884 | pubmed:author | pubmed-author:ChaouatGG | lld:pubmed |
| pubmed-article:8118884 | pubmed:author | pubmed-author:MogilRR | lld:pubmed |
| pubmed-article:8118884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8118884 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:8118884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8118884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8118884 | pubmed:pagination | 143-52 | lld:pubmed |
| pubmed-article:8118884 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8118884 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8118884 | pubmed:articleTitle | Prevention of spontaneous abortion in DBA/2-mated CBA/J mice by GM-CSF involves CD8+ T cell-dependent suppression of natural effector cell cytotoxicity against trophoblast target cells. | lld:pubmed |
| pubmed-article:8118884 | pubmed:affiliation | Department of Medicine, McMaster University, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:8118884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8118884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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