Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0000786,
umls-concept:C0025923,
umls-concept:C0041178,
umls-concept:C0079460,
umls-concept:C0085358,
umls-concept:C0205296,
umls-concept:C0221284,
umls-concept:C0301625,
umls-concept:C0312740,
umls-concept:C0596402,
umls-concept:C1260899,
umls-concept:C1314939,
umls-concept:C1332717,
umls-concept:C1335641,
umls-concept:C1413244,
umls-concept:C1416894,
umls-concept:C1511406,
umls-concept:C1706158,
umls-concept:C1706438,
umls-concept:C1708528,
umls-concept:C2698600
|
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-4-6
|
| pubmed:abstractText |
Spontaneous resorption (abortion) that occurs at a high rate in DBA/2-mated CBA/J female mice is dependent upon asialoGM1+ natural effector-type cells, can be ameliorated by alloimmunization or administration of GM-CSF, and is augmented by in vivo injection of anti-CD8 antibody. The abortion rate was similarly augmented by administration of monoclonal anti-GM-CSF neutralizing antibody, but the GM-CSF physiologically active in preventing abortion during normal pregnancy did not appear to be derived from maternal CB8+ T cells putatively responding to antigens on the fetoplacental unit. Rather, depletion of CD8+ cells in vivo prevented GM-CSF from reducing the rate of resorptions. GM-CSF administration rapidly downregulates natural effector cells able to kill a trophoblast target cell line in vitro, and anti-CD8+ antibody boosts total splenic cytotoxic cell activity. Further, anti-CD8 completely abrogated the ability of GM-CSF to suppress anti-trophoblast killer cell activity. These cells are known to be asialoGM1+ and injection of anti-asialoGM1 reduced the abortion rate appropriately in mice that had received anti-CD8. These data suggest that GM-CSF acts indirectly to prevent abortion in DBA/2-mated CBA/J mice through a mechanism that requires CD8+ maternal T cells, and systemic regulation of the level of anti-trophoblast killer cell activity may determine the success or failure of pregnancy in this system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/G(M1) Ganglioside,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/asialo GM1 ganglioside
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0008-8749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
154
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
143-52
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8118884-Abortion, Spontaneous,
pubmed-meshheading:8118884-Animals,
pubmed-meshheading:8118884-Antibodies,
pubmed-meshheading:8118884-Antigens, CD8,
pubmed-meshheading:8118884-Cytotoxicity, Immunologic,
pubmed-meshheading:8118884-Female,
pubmed-meshheading:8118884-Fetal Resorption,
pubmed-meshheading:8118884-G(M1) Ganglioside,
pubmed-meshheading:8118884-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:8118884-Immune Tolerance,
pubmed-meshheading:8118884-Killer Cells, Natural,
pubmed-meshheading:8118884-Male,
pubmed-meshheading:8118884-Mice,
pubmed-meshheading:8118884-Mice, Inbred CBA,
pubmed-meshheading:8118884-Mice, Inbred DBA,
pubmed-meshheading:8118884-Pregnancy,
pubmed-meshheading:8118884-T-Lymphocyte Subsets,
pubmed-meshheading:8118884-Trophoblasts
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Prevention of spontaneous abortion in DBA/2-mated CBA/J mice by GM-CSF involves CD8+ T cell-dependent suppression of natural effector cell cytotoxicity against trophoblast target cells.
|
| pubmed:affiliation |
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|