| pubmed-article:8118801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8118801 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:8118801 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:8118801 | lifeskim:mentions | umls-concept:C1517342 | lld:lifeskim |
| pubmed-article:8118801 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8118801 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8118801 | pubmed:dateCreated | 1994-4-7 | lld:pubmed |
| pubmed-article:8118801 | pubmed:abstractText | The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to determine the relationship between the expression of WAF1/CIP1 and endogenous regulation of p53 function. WAF1/CIP1 protein was first localized to the nucleus of cells containing wild-type p53 and undergoing G1 arrest. WAF1/CIP1 was induced in wild-type p53-containing cells by exposure to DNA damaging agents, but not in mutant p53-containing cells. The induction of WAF1/CIP1 protein occurred in cells undergoing either p53-associated G1 arrest or apoptosis but not in cells induced to arrest in G1 or to undergo apoptosis through p53-independent mechanisms. DNA damage led to increased levels of WAF1/CIP1 in cyclin E-containing complexes and to an associated decrease in cyclin-dependent kinase activity. These results support the idea that WAF1/CIP1 is a critical downstream effector in the p53-specific pathway of growth control in mammalian cells. | lld:pubmed |
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| pubmed-article:8118801 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8118801 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8118801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8118801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8118801 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8118801 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:HarperJ WJW | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:WangYY | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:HillD EDE | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:BurrellMM | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:O'ConnorP MPM | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:el-DeiryW SWS | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:PietenpolJ... | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:CanmanC ECE | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:JackmanJJ | lld:pubmed |
| pubmed-article:8118801 | pubmed:author | pubmed-author:VelculescuV... | lld:pubmed |
| pubmed-article:8118801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8118801 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8118801 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:8118801 | pubmed:geneSymbol | p53 | lld:pubmed |
| pubmed-article:8118801 | pubmed:geneSymbol | v-myc | lld:pubmed |
| pubmed-article:8118801 | pubmed:geneSymbol | WAF1/CIP1 | lld:pubmed |
| pubmed-article:8118801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8118801 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8118801 | pubmed:pagination | 1169-74 | lld:pubmed |
| pubmed-article:8118801 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8118801 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8118801 | pubmed:articleTitle | WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. | lld:pubmed |
| pubmed-article:8118801 | pubmed:affiliation | Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231. | lld:pubmed |
| pubmed-article:8118801 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8118801 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8118801 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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