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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1994-4-1
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pubmed:abstractText |
Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-gamma (IFN gamma). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFN gamma in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
83
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1408-11
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8118042-Base Sequence,
pubmed-meshheading:8118042-Cells, Cultured,
pubmed-meshheading:8118042-DNA Primers,
pubmed-meshheading:8118042-Enzyme Induction,
pubmed-meshheading:8118042-Gene Expression,
pubmed-meshheading:8118042-Humans,
pubmed-meshheading:8118042-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:8118042-Interferon-gamma,
pubmed-meshheading:8118042-Interleukin-4,
pubmed-meshheading:8118042-Molecular Sequence Data,
pubmed-meshheading:8118042-Monocytes,
pubmed-meshheading:8118042-RNA, Messenger,
pubmed-meshheading:8118042-Tryptophan,
pubmed-meshheading:8118042-Tryptophan Oxygenase
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pubmed:year |
1994
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pubmed:articleTitle |
Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes.
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pubmed:affiliation |
Biological Carcinogenesis and Development Program, PRI/DynCorp, Turin, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro
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