Linked Life Data

8117834

Source:http://linkedlifedata.com/resource/pubmed/id/8117834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-4-6
pubmed:abstractText
It has earlier been established that conjugates of hydrophilic proteins with block copolymers of ethylene oxide and propylene oxide (proxanols) used at low concentrations decrease the oxidation of NAD-dependent substrates in mitochondria and cells. The dependence of this property on the chemical structure and structural organization of such conjugates has been studied. The conjugates have been shown to inhibit the oxygen consumption of lymphocytes when the hydrophobic (polypropylene oxide) blocks are located on the periphery of the conjugate and the polymer chains form domains that are irregularly distributed on the protein globule surface. The minimum number of the polymer chains in the conjugate sufficient to provide this property is three. Additional evidence has been obtained in favour of the ability of conjugates to penetrate through the cellular membrane of lymphocytes.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0320-9725
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-22
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Membranotropic properties of conjugates of proteins with ethylene oxide and propylene oxide block copolymers].
pubmed:publicationType
Journal Article, English Abstract