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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-4-7
|
| pubmed:abstractText |
We report the outcome of 121 cadaveric renal transplants performed in our institution between September 1985 and April 1992 in 117 patients, aged 60-71 years (mean 63 years) at the time of transplantation. Compared to 640 patients 20-59 years of age transplanted during the same study period, a nonstatistically significant difference was observed in the 5-year actuarial patient (80% and 90%, respectively, in recipients over and under 60 years of age) and transplant (80% and 72%, respectively, in recipients over and under 60 years of age) survival rates. However, elderly patients had significantly lower survival than recipients 20-29 years of age (P < 0.009). Fourteen patients died (all but one with a functioning graft) due to cardiovascular diseases (5%; 42.8% of total deaths), infections (3%; 28.6% of total deaths), and gastrointestinal complications (3%; 28.6% of total deaths). Younger patients showed a similar and nonsignificantly different incidence of cardiovascular- (35%) and infectious-(30%) related deaths. The incidence of acute rejection episodes and cytomegalovirus (CMV) infectious episodes was 27% and 24%, respectively, during the 1st post-transplant year. Ongoing acute rejection and CMV infectious episodes were significantly higher in patients who died than in those still alive (P < 0.002 and P < 0.02, respectively). Cyclosporin maintenance therapy was well tolerated in all patients but one, and 64% of the patients could be maintained without steroids. These data indicate that cadaveric renal transplantation is a safe and effective procedure in the management of chronic renal failure of selected patients 60 years of age or older.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0934-0874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
33-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8117400-Adolescent,
pubmed-meshheading:8117400-Adult,
pubmed-meshheading:8117400-Age Factors,
pubmed-meshheading:8117400-Aged,
pubmed-meshheading:8117400-Cadaver,
pubmed-meshheading:8117400-Child,
pubmed-meshheading:8117400-Child, Preschool,
pubmed-meshheading:8117400-Female,
pubmed-meshheading:8117400-Follow-Up Studies,
pubmed-meshheading:8117400-Graft Survival,
pubmed-meshheading:8117400-Humans,
pubmed-meshheading:8117400-Immunosuppressive Agents,
pubmed-meshheading:8117400-Infant,
pubmed-meshheading:8117400-Kidney Transplantation,
pubmed-meshheading:8117400-Male,
pubmed-meshheading:8117400-Middle Aged,
pubmed-meshheading:8117400-Reoperation,
pubmed-meshheading:8117400-Tissue Donors,
pubmed-meshheading:8117400-Treatment Outcome
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Cadaveric renal transplantation after 60 years of age. A single center experience.
|
| pubmed:affiliation |
Service de Néphrologie et Immunologie Clinique, Centre Hospitalier, Nantes, France.
|
| pubmed:publicationType |
Journal Article
|