| pubmed-article:8117316 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8117316 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8117316 | lifeskim:mentions | umls-concept:C0026030 | lld:lifeskim |
| pubmed-article:8117316 | lifeskim:mentions | umls-concept:C0022265 | lld:lifeskim |
| pubmed-article:8117316 | lifeskim:mentions | umls-concept:C1880989 | lld:lifeskim |
| pubmed-article:8117316 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8117316 | pubmed:dateCreated | 1994-3-25 | lld:pubmed |
| pubmed-article:8117316 | pubmed:abstractText | Glucuronidation and isomerization of all-trans-retinoic acid (tr-RA) and 13-cis-retinoic acid (13-cis-RA) were investigated in an in vitro system using liver microsomes of differently pretreated rats. In agreement with their thermodynamic stability, more retinoic acid was isomerized from the 13-cis form to the all-trans form than vice versa. Also some 9-cis-retinoic acid (9-cis-RA) could be found. Isomerization was reduced, but in contrast to glucuronidation was still important if boiled microsomes were used. This supports the view that isomerization can proceed as a non-enzymatic process. 3-Methylcholanthrene (MC) pretreatment of the rats increased the microsomal glucuronidation of 13-cis-RA and tr-RA and the formation of 13-cis-retinoyl-beta-glucuronide was enhanced up to 7-fold by MC-induced rat microsomes. The rates of glucuronidation by uninduced and phenobarbital-induced rat microsomes differed only slightly. In addition to glucuronides of the applied retinoic acid isomers (13-cis-RA and tr-RA), 9-cis-RA and its glucuronide were found. Induction of retinoid glucuronidation by pretreatment with MC indicates that this metabolic reaction is catalysed by a MC-inducible UGT isozyme. After two recently described pathways (conversions of retinol to retinal and of retinyl methyl ether to retinol) this is a third step of retinoid metabolism, induced by pretreatment with MC. With human microsomes no more than traces of glucuronides were detected; also, incubations with human microsomes resulted in a lower degree of isomerization than with rat microsomal fractions. | lld:pubmed |
| pubmed-article:8117316 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8117316 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8117316 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8117316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8117316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8117316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8117316 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8117316 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8117316 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8117316 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:8117316 | pubmed:author | pubmed-author:BockK WKW | lld:pubmed |
| pubmed-article:8117316 | pubmed:author | pubmed-author:ForsterAA | lld:pubmed |
| pubmed-article:8117316 | pubmed:author | pubmed-author:ODAFF | lld:pubmed |
| pubmed-article:8117316 | pubmed:author | pubmed-author:SassJ OJO | lld:pubmed |
| pubmed-article:8117316 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8117316 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:8117316 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:8117316 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8117316 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8117316 | pubmed:pagination | 485-92 | lld:pubmed |
| pubmed-article:8117316 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:meshHeading | pubmed-meshheading:8117316-... | lld:pubmed |
| pubmed-article:8117316 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8117316 | pubmed:articleTitle | Glucuronidation and isomerization of all-trans- and 13-cis-retinoic acid by liver microsomes of phenobarbital- or 3-methylcholanthrene-treated rats. | lld:pubmed |
| pubmed-article:8117316 | pubmed:affiliation | Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin, Germany. | lld:pubmed |
| pubmed-article:8117316 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8117316 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8117316 | lld:pubmed |
