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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-3-25
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pubmed:abstractText |
Two series of experiments were done to investigate the mechanism underlying arginine8-vasopressin (AVP)-induced barrel rotation in rats. In the first series, the effect of intracerebroventricular (ICV) administration of various neurohypophyseal hormone antagonists on AVP-induced barrel rotation was studied. The more vasopressin was given, the more the rats exhibited barrel rotation. ICV pretreatment with a V1 vasopressin receptor antagonist, d(CH2)5[Tyr(Me)2]AVP, prevented barrel rotation, while similar treatment with a V2-antagonist, d(CH2)5[dIle2Ile4]AVP, did not affect vasopressin-induced barrel rotation. However, Des-Gly,NH2d(CH2)5[Tyr)Me2)Thr4Orn8]-vasotocin, a specific oxytocin antagonist, potentiated the effect of AVP on barrel rotation. The second experiment was performed in rats equipped with a telemetry system to measure heart rate (HR), core temperature (CT), and gross locomotor activity. Also, in this experiment the incidence of AVP-induced barrel rotation was dose-dependent, as was the number of rats that died. Barrel rotation was accompanied by a significant decrease in CT and HR, while rats that did not develop hypothermia did not show barrel rotation. These results suggest that a V1 receptor is involved in barrel rotation. Since AVP-induced hypothermia is also mediated by a V1 receptor, it is postulated that hypothermia is a prerequisite for barrel rotation to occur. Further experiments are needed to substantiate this hypothesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0091-3057
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8115425-Animals,
pubmed-meshheading:8115425-Arginine Vasopressin,
pubmed-meshheading:8115425-Body Temperature,
pubmed-meshheading:8115425-Dose-Response Relationship, Drug,
pubmed-meshheading:8115425-Heart Rate,
pubmed-meshheading:8115425-Injections, Intraventricular,
pubmed-meshheading:8115425-Male,
pubmed-meshheading:8115425-Motor Activity,
pubmed-meshheading:8115425-Neuropeptides,
pubmed-meshheading:8115425-Rats,
pubmed-meshheading:8115425-Rats, Wistar,
pubmed-meshheading:8115425-Receptors, Pituitary Hormone,
pubmed-meshheading:8115425-Stereotyped Behavior
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pubmed:year |
1994
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pubmed:articleTitle |
Barrel rotation induced by central arginine8-vasopressin treatment: involvement of neurohypophyseal peptide receptors.
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pubmed:affiliation |
Rudolf Magnus Institute, Utrecht University, The Netherlands.
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pubmed:publicationType |
Journal Article
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