Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-3-30
pubmed:abstractText
1,25-dihydroxyvitamin D3[1,25(OH)2D3] suppresses parathyroid hormone (PTH) gene transcription. Recent evidence suggests that retinoid X receptors are involved in 1,25(OH)2D3-mediated transcriptional events. However, little data exists for a role of retinoids in parathyroid function or in PTH expression. In the present study, we observed that all-trans- or 9-cis retinoic acid suppressed the release of PTH from bovine parathyroid cell cultures. Both retinoids were remarkably potent with significant decreases evident at 10(-10) M and a maximally suppressive effect (approximately 65%) at 10(-7) M. All-trans-retinol was considerably less potent in this system. The effect was not evident until 12 h, suggesting that retinoids did not affect the rapid secretion of preexisting PTH stores. PreproPTH mRNA levels were also suppressed by retinoic acid and the retinoid potencies were similar to those observed in the secretion studies. Combined treatment with 10(-6) M retinoic acid and 10(-8) M 1,25(OH)2D3 more effectively decreased PTH secretion and preproPTH mRNA than did either compound alone. These data indicate that retinoic acid: (a) elicits a bioresponse in bovine parathyroid cells; (b) attenuates PTH expression at the protein and mRNA levels, and (c) acts independently of 1,25(OH)2D3 in the control of PTH expression.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1141439, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1309942, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1310260, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1310351, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1314167, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1327537, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1376958, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1527087, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1655763, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1660470, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-1662118, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-2159111, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-2175914, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-2294409, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3371268, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3491624, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3494246, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3680521, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3771798, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3780554, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3840080, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3858880, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-3958806, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-408151, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-4101634, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-4641958, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-496005, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-6549016, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-6862097, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-744006, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-8382345, http://linkedlifedata.com/resource/pubmed/commentcorrection/8113407-8395017
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
725-30
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Retinoic acid suppresses parathyroid hormone (PTH) secretion and PreproPTH mRNA levels in bovine parathyroid cell culture.
pubmed:affiliation
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.