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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5-6
|
| pubmed:dateCreated |
1994-3-30
|
| pubmed:abstractText |
We studied 122 relatives (18 parents, 33 siblings, 57 offspring, 10 nephews and 4 nieces; mean age 34 +/- 19 years) of 33 patients with hypertrophic cardiomyopathy (HC) to analyze the incidence and clinical significance of electrocardiographic and echocardiographic abnormalities. On the basis of conventional echocardiographic criteria 12 first-degree relatives were considered to be affected by HC. Thirteen first-degree relatives and 1 niece were judged as having probable but not definite HC, i.e. left ventricular (LV) wall thicknesses over the 95% upper limit of confidence interval for age and body surface area or borderline ventricular septal thickness but a septal-to-free wall thickness ratio > or = 1.3 in the absence of an identifiable origin. Ninety relatives had normal echocardiographic findings. The remaining 6 subjects were found to have essential hypertension and were therefore excluded from consideration. Electrocardiogram (ECG) showed major or minor abnormalities in all relatives with HC, in 7 of the 14 probably affected by HC and in 20 of the 90 with normal echocardiogram. Of the 122 relatives 44 (38 with normal echocardiogram and 6 probably affected by HC) were reexamined over a mean period of 4.3 years (range 2-7). In the course of the follow-up 3 subjects modified their cardiac status. Two offspring who had at entry LV hypertrophy at ECG as isolated cardiac abnormality developed HC over a period of 5 years. A sibling who had only minor electrocardiographic abnormalities in the first study became probably affected by HC 3 years later.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0008-6312
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
289-97
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| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8111761-Adolescent,
pubmed-meshheading:8111761-Adult,
pubmed-meshheading:8111761-Aged,
pubmed-meshheading:8111761-Cardiomyopathy, Hypertrophic,
pubmed-meshheading:8111761-Child,
pubmed-meshheading:8111761-Child, Preschool,
pubmed-meshheading:8111761-Echocardiography,
pubmed-meshheading:8111761-Electrocardiography,
pubmed-meshheading:8111761-Female,
pubmed-meshheading:8111761-Follow-Up Studies,
pubmed-meshheading:8111761-Heterozygote,
pubmed-meshheading:8111761-Humans,
pubmed-meshheading:8111761-Infant,
pubmed-meshheading:8111761-Male,
pubmed-meshheading:8111761-Middle Aged,
pubmed-meshheading:8111761-Pedigree
|
| pubmed:year |
1993
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| pubmed:articleTitle |
The spectrum of echocardiographic and electrocardiographic abnormalities in nonaffected relatives of patients with hypertrophic cardiomyopathy: a transverse and longitudinal study.
|
| pubmed:affiliation |
Department of Internal Medicine, School of Cardiovascular Diseases, University of Rome Tor Vergata, Italy.
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| pubmed:publicationType |
Journal Article
|