| pubmed-article:8106177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8106177 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8106177 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:8106177 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:8106177 | lifeskim:mentions | umls-concept:C1154413 | lld:lifeskim |
| pubmed-article:8106177 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:8106177 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8106177 | pubmed:dateCreated | 1993-12-1 | lld:pubmed |
| pubmed-article:8106177 | pubmed:abstractText | Gap junctional intercellular communication (IC) was studied in gamma-glutamyltranspeptidase (gamma-GT)-positive and -negative hepatocytes isolated from carcinogen-treated rats. Putative preneoplastic gamma-GT-positive hepatocytes were visualized in monolayer cultures by indirect immunofluorescence using anti-gamma-GT-antibodies. IC was evaluated by studying dye coupling of the cells. gamma-GT-positive hepatocytes showed a significantly lower dye coupling than did gamma-GT-negative liver cells. Spread of the dye Lucifer Yellow CH to neighboring cells was decreased further by the tumor-promoting chemical phenobarbital in both cell types in vitro. Also treatment in vivo with the barbiturate significantly reduced dye coupling of hepatocytes. The findings suggest that as a result of their decreased ability to communicate, preneoplastic hepatocytes may escape from growth control and differentiation signals given out by surrounding 'normal' cells. | lld:pubmed |
| pubmed-article:8106177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8106177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8106177 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8106177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8106177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8106177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8106177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8106177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8106177 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8106177 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:8106177 | pubmed:author | pubmed-author:SchwarzL RLR | lld:pubmed |
| pubmed-article:8106177 | pubmed:author | pubmed-author:LeiboldEE | lld:pubmed |
| pubmed-article:8106177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8106177 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:8106177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8106177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8106177 | pubmed:pagination | 2127-9 | lld:pubmed |
| pubmed-article:8106177 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:meshHeading | pubmed-meshheading:8106177-... | lld:pubmed |
| pubmed-article:8106177 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8106177 | pubmed:articleTitle | Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes. | lld:pubmed |
| pubmed-article:8106177 | pubmed:affiliation | GSF-Institut für Toxikologie, Oberschleissheim, Germany. | lld:pubmed |
| pubmed-article:8106177 | pubmed:publicationType | Journal Article | lld:pubmed |
