Linked Life Data

8106177

Source:http://linkedlifedata.com/resource/pubmed/id/8106177

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1993-12-1
pubmed:abstractText
Gap junctional intercellular communication (IC) was studied in gamma-glutamyltranspeptidase (gamma-GT)-positive and -negative hepatocytes isolated from carcinogen-treated rats. Putative preneoplastic gamma-GT-positive hepatocytes were visualized in monolayer cultures by indirect immunofluorescence using anti-gamma-GT-antibodies. IC was evaluated by studying dye coupling of the cells. gamma-GT-positive hepatocytes showed a significantly lower dye coupling than did gamma-GT-negative liver cells. Spread of the dye Lucifer Yellow CH to neighboring cells was decreased further by the tumor-promoting chemical phenobarbital in both cell types in vitro. Also treatment in vivo with the barbiturate significantly reduced dye coupling of hepatocytes. The findings suggest that as a result of their decreased ability to communicate, preneoplastic hepatocytes may escape from growth control and differentiation signals given out by surrounding 'normal' cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2127-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
pubmed:affiliation
GSF-Institut für Toxikologie, Oberschleissheim, Germany.
pubmed:publicationType
Journal Article