Linked Life Data

8106005

Source:http://linkedlifedata.com/resource/pubmed/id/8106005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1993-11-29
pubmed:abstractText
We explored the consequences of postnatal day 1 (P1) intrastriatal 6-hydroxydopamine (6-OHDA) lesions on the developing mesostriatal dopamine system by performing in situ hybridization histochemistry for tyrosine hydroxylase (TH) in the substantia nigra-ventral tegmental area (SN-VTA) complex of neonatally-lesioned and non-lesioned animals at P90. There were significant reductions in the expression of TH mRNA from both the rostral and caudal levels of the lateral and medial SNc of 6-OHDA treated animals. The VTA was preferentially spared from the neurotoxic effects of 6-OHDA and showed elevated levels of TH mRNA in the caudal VTA compared with controls. This heterogeneous pattern of TH mRNA expression suggests that early intrastriatal 6-OHDA lesions selectively damage certain DA systems and affect the development of other systems.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1095-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Neonatal 6-OHDA lesions upregulate adult expression of tyrosine hydroxylase mRNA.
pubmed:affiliation
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104-6141.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.