rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1993-12-1
|
pubmed:abstractText |
It was postulated that chronic blockade of the opioid system in neuroleptic-stabilized schizophrenic patients would have a beneficial behavioral effect. Eleven neuroleptic-stabilized psychotic inpatients received augmentation with nalmefene for an average of 36.7 days in a double-blind placebo-controlled study. The patients exhibited significant reductions in Bunney-Hamburg psychosis ratings and the Brief Psychiatric Rating Scale thinking disturbance subscale during the augmentation period. This study presents preliminary data supporting the hypothesis that chronic augmentation of neuroleptic-stabilized schizophrenic patients with opiate antagonists is beneficial.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0893-133X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
111-5
|
pubmed:dateRevised |
2011-5-18
|
pubmed:meshHeading |
pubmed-meshheading:8105790-Adolescent,
pubmed-meshheading:8105790-Adult,
pubmed-meshheading:8105790-Antipsychotic Agents,
pubmed-meshheading:8105790-Double-Blind Method,
pubmed-meshheading:8105790-Drug Therapy, Combination,
pubmed-meshheading:8105790-Female,
pubmed-meshheading:8105790-Homovanillic Acid,
pubmed-meshheading:8105790-Humans,
pubmed-meshheading:8105790-Hydrocortisone,
pubmed-meshheading:8105790-Male,
pubmed-meshheading:8105790-Methoxyhydroxyphenylglycol,
pubmed-meshheading:8105790-Naltrexone,
pubmed-meshheading:8105790-Narcotic Antagonists,
pubmed-meshheading:8105790-Prolactin,
pubmed-meshheading:8105790-Psychiatric Status Rating Scales,
pubmed-meshheading:8105790-Schizophrenia,
pubmed-meshheading:8105790-Schizophrenic Psychology
|
pubmed:year |
1993
|
pubmed:articleTitle |
Beneficial effects of nalmefene augmentation in neuroleptic-stabilized schizophrenic patients.
|
pubmed:affiliation |
Department of Psychiatry, University of California, San Diego.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|