Linked Life Data

8105485

Source:http://linkedlifedata.com/resource/pubmed/id/8105485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-11-17
pubmed:abstractText
The effect of voluntary exercise on 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB)-induced hepatomas was investigated in male Jc1:Wistar rats. Beginning at 10 weeks of age, animals were divided into two groups (sedentary and exercise) and housed in individual cages. Food intake and wheel exercise were automatically controlled in the cages of the exercise group. Body weights were monitored throughout the study. Food availability was controlled in order to equate length and weight gain. From 27 weeks to termination of the study at 62 weeks, all animals were administered 3'-Me-DAB in the diet at a dose level of 0.0177 g/day/kg body wt. All animals were sacrificed at 62 weeks of age. The incidence of hepatomas was significantly lower in the exercise group as compared with the sedentary group (0% and 65%, respectively). Liver weight was significantly greater in the exercise group compared with sedentary animals without hepatomas. The weight of epididymal fat pads was significantly lower in the exercise group. Serum alkaline phosphate was significantly higher in the exercise group as compared with the sedentary group. Serum gamma-glutamyl-transpeptidase levels were higher in the sedentary group than in the exercise group. In addition, gamma-glutamyl-transpeptidase levels were significantly higher in sedentary animals with hepatomas than in sedentary animals without hepatomas. These results demonstrate that voluntary exercise decreases 3'-Me-DAB-induced hepatomas and that this decrease is associated with an increase in serum alkaline phosphatase and a decrease in serum gamma-glutamyl-transpeptidase levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
204
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of voluntary exercise on 3'-methyl-4-dimethylaminoazobenzene-induced hepatomas in male Jc1:Wistar rats.
pubmed:affiliation
Physical Fitness Research Institute, Meiji Life Foundation and Welfare, Tokyo, Japan.
pubmed:publicationType
Journal Article