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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-11-5
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pubmed:abstractText |
In order to investigate the function of CD2 and CD18 receptors in antibody-dependent cellular cytotoxicity (ADCC), Fab' fragments of the monoclonal antibodies 9.6 (anti-CD2) and 60.3 (anti-CD18) were preincubated with the human natural killer (NK) clone EB4.19 and tested for conjugate formation and cytotoxic function against the human B-cell line KMS and the mouse thymoma line SL-2. We concluded that: (1) the FcR CD16 does not participate in conjugate formation; (2) adhesion between target and effector cells mediated by CD2 and CD18 is a prerequisite for subsequent activation of the lytic programme through the CD16 receptor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-1708296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-2021423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-2434840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-2697680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-2892600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-2903193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-2952730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-2961052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-3084649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-3284289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-3302041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-6233371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-6610556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-6644024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8104886-6788841
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukocyte-Adhesion
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8104886-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:8104886-Antigens, CD,
pubmed-meshheading:8104886-Antigens, CD18,
pubmed-meshheading:8104886-Antigens, CD2,
pubmed-meshheading:8104886-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:8104886-Cell Adhesion,
pubmed-meshheading:8104886-Cells, Cultured,
pubmed-meshheading:8104886-Humans,
pubmed-meshheading:8104886-Killer Cells, Natural,
pubmed-meshheading:8104886-Receptors, IgG,
pubmed-meshheading:8104886-Receptors, Immunologic,
pubmed-meshheading:8104886-Receptors, Leukocyte-Adhesion
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pubmed:year |
1993
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pubmed:articleTitle |
Adhesion of CD16+ K cells to antibody-coated targets is mediated by CD2 and CD18 receptors.
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pubmed:affiliation |
Fred Hutchinson Cancer Research Center, Seattle, Washington.
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pubmed:publicationType |
Journal Article
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