Linked Life Data

8104809

Source:http://linkedlifedata.com/resource/pubmed/id/8104809

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1993-11-9
pubmed:abstractText
The present study investigated the effects of a alpha 2-adrenoceptor agonist, D-medetomidine (0.3, 3.0, 30.0 and 300.0 micrograms/kg, s.c.), on neocortical EEG activity in control and 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats. D-Medetomidine at 0.3, 3.0, and 30.0 micrograms/kg dose dependently increased waking-immobility-related high-voltage spike and wave spindles. Movement and waking-immobility-related slow wave activity was increased at doses of 3.0, 30.0 and 300.0 micrograms/kg. D-Medetomidine at 300.0 micrograms/kg produced continuous 1-2 Hz slow wave activity and the animals were markedly sedated. In rats injected with D-medetomidine at 0.3, 3.0 and 30.0, micrograms/kg EEG activity could be desynchronized (block of high-voltage spindles and slow waves) by pinching the tail. However, rats injected with D-medetomidine at 300.0 micrograms/kg showed no change in EEG activity or behavior following tail pinching. D-Medetomidine induced similar EEG activity (high-voltage spindles and slow waves) and behavioral changes (sedation) in 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats. Atipamezole, an alpha 2-adrenoceptor antagonist, blocked D-medetomidine-induced EEG and behavioral changes in control and 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats. Based on the present results we suggest that stimulation of presynaptic noradrenergic fibers is not a prerequisite for the increase of high-voltage spindle and slow wave activity induced by an alpha 2-adrenoceptor agonist and that the magnitude of EEG slowing induced by D-medetomidine correlates with the decreased behavioral response to sensory stimulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
238
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The effects of alpha 2-adrenoceptor stimulation on neocortical EEG activity in control and 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats.
pubmed:affiliation
University of Kuopio, Department of Neurology, A.I. Virtanen Institute, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't