Linked Life Data

8104594

Source:http://linkedlifedata.com/resource/pubmed/id/8104594

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-11-23
pubmed:abstractText
Out of 148 patients who had metastatic adenocarcinoma of the lung and were referred to Chang Gung Memorial Hospital for treatment from 1979 to 1987, 20% had symptomatic brain metastases. We have attempted to determine the subset of high-risk patients who might benefit from prophylactic cranial irradiation. In 25 patients with a complete remission, 36% (n = 9) eventually developed brain metastases after a minimum follow-up of 24 months. Patients with initial mediastinal node metastases showed a higher incidence of brain metastases (75%) than those harboring only hilar node metastases (25%, p = 0.03). Age, sex, tumor location and clinical staging had no significant correlation in the prognosis of brain metastases. Since the median recurrence-free survival rate of six months for patients with brain metastases was significantly shorter than for those without (14 months), we recommend that prophylactic cranial irradiation be conducted in complete responders with mediastinal nodal lesions to see if such treatment will prolong patients' recurrence-free survival via a reduction in brain metastases, thus improving their quality of life.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0929-6646
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
413-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Impact of prophylactic cranial irradiation in adenocarcinoma of the lung.
pubmed:affiliation
Department of Radiation Oncology, Chang Gung Memorial Hospital, Tao-Yuan County, Taiwan, R.O.C.
pubmed:publicationType
Journal Article