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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4-5
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pubmed:dateCreated |
1993-9-30
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pubmed:abstractText |
The use of phenylboronic acid (PBA) solid-phase extraction cartridges for the extraction of a range of beta-blockers from aqueous buffer and plasma has been investigated and compared with other phases commonly used for solid-phase extraction. PBA was found to provide an efficient means for the extraction of this class of compound from simple aqueous buffer systems. Extraction from buffers was pH-dependent and gave optimum results at approximately pH 8. Extraction from plasma was less efficient for some of the test compounds; this matrix effect was probably due to protein binding. Chromatography showed that plasma extracts were free of major sources of interference.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0731-7085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-12
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8102883-Adrenergic beta-Antagonists,
pubmed-meshheading:8102883-Animals,
pubmed-meshheading:8102883-Boronic Acids,
pubmed-meshheading:8102883-Buffers,
pubmed-meshheading:8102883-Humans,
pubmed-meshheading:8102883-Hydrogen-Ion Concentration,
pubmed-meshheading:8102883-Propranolol,
pubmed-meshheading:8102883-Protein Binding,
pubmed-meshheading:8102883-Rats,
pubmed-meshheading:8102883-Silica Gel,
pubmed-meshheading:8102883-Silicon Dioxide,
pubmed-meshheading:8102883-Spectrophotometry, Ultraviolet
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pubmed:articleTitle |
Immobilized phenylboronic acids for the selective extraction of beta-blocking drugs from aqueous solution and plasma.
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pubmed:affiliation |
Department of Safety of Medicines, ICI Pharmaceuticals, Alderly Park, Macclesfield, UK.
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pubmed:publicationType |
Journal Article
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