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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1993-9-23
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pubmed:databankReference |
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pubmed:abstractText |
POU domain proteins have been implicated in the regulation of a number of lineage-specific genes. Among the first POU domain proteins described were the immunoglobulin octamer-binding proteins Oct-1 and Oct-2. It was therefore of special interest when we identified a novel lymphoid POU domain protein in Southwestern (DNA-protein) screens of T-cell lambda gt11 libraries. This novel POU protein, TCF beta 1, binds in a sequence-specific manner to a critical motif in the T-cell receptor (TCR) beta enhancer. Sequence analysis revealed that TCF beta 1 represents a new class of POU domain proteins which are distantly related to other POU proteins. TCF beta 1 is encoded by multiple exons whose organization is distinct from that of other POU domain proteins. The expression of TCF beta 1 in a tissue-restricted manner and its ability to bind to multiple motifs in the TCR beta enhancer support a role in regulating TCR beta gene expression. The expression of TCF beta 1 in both B and T cells and the ability of recombinant TCF beta 1 to bind octamer and octamer-related motifs suggest that TCF beta 1 has additional roles in lymphoid cell function. The ability of TCF beta 1 to transactivate in a sequence-specific manner is consistent with a role for regulating lymphoid gene expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1346754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1359428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1387667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1423591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1509262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1509263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1531412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1534408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1628619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1677216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1683003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1732736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1739980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1827068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1871134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1901381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1904384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1976089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1977085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-1991317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2010091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2044958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2123291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2144608,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2153177,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2307370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2328728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2504497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2530301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2557542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2698648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2739723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2902928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2903797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2904654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2905684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2964277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2968651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-2983227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-3109035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-3118372,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-3265124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-3396541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-3627254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-3871511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-3873070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102789-8464876
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:geneSymbol |
Brn-1,
Brn-3,
Oct1,
Oct2,
Oct4,
TCF&bgr;1,
cfla1,
unc-86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5450-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
