Linked Life Data

8102528

Source:http://linkedlifedata.com/resource/pubmed/id/8102528

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-9-14
pubmed:abstractText
Synthesis of esters containing 2 (N,N-dialkylamino) ethanolic and 2-alkoxyethanolic groups with heteroaryl acids was carried out. Three series of such esters: (2-substituted-3,4-dihydro-4-oxo-quniazolin-3-yl) acetates, S-(3-aryl-3,4-dihydro-4-oxo-quinazolin-2-yl) mercaptoacates and S-(1H-benzimidazol-2-yl) mercaptoacetates were synthesized from their respective acids/acid chlorides using appropriate alcohols. Their in vivo H1-antihistaminic potencies were evaluated using isolated guinea pig ileum method. The IC50 values indicate higher potencies of quinazolinonyl mercaptoacetates than the other two series, in general. Presence of an aryl group at position 3, with an electron-releasing substituent appears to enhance the antihistaminic activity. Similarly 2 (N,N-diethylamino) ethyl esters were found to be more active than the other type of esters tested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
663-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
New esters of heteryl acetic and mercaptoacetic acids. Synthesis and H1-antihistaminic evaluation.
pubmed:affiliation
Medicinal Chemistry Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't