Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-9-10
pubmed:abstractText
The mechanism of CD4+ cell depletion and functional T helper cell inhibition in HIV-infected individuals is poorly understood. The present study demonstrates that immune complex-covered CD4+ cells are associated with T cell inhibition and macrophage stimulation. We studied 30 patients with ARC/AIDS and 35 asymptomatic HIV+ haemophilia patients. Overall, 20 +/- 3% of peripheral CD4+ lymphocytes were covered with gp120 (range 0-94%). gp120+ cells also exhibited surface-bound IgG (P = 0.0001), IgM (P = 0.0001), and complement (P = 0.0001). Decreased in vitro lymphocyte proliferation was associated with the immune complex load of CD4+ cells. The higher the percentage of CD4+ gp 120+ cells in the blood, the lower the T cell response in vitro (P = 0.001). Moreover, an association was found between immune complex-positive cells and plasma neopterin (P = 0.01). Patients with increased plasma neopterin levels had decreased in vitro responses to pokeweed mitogen (PWM) (P = 0.006), phytohaemagglutinin (PHA) (P = 0.004), concanavalin A (Con A) (P = 0.09), and anti-CD3 MoAb (P = 0.03), and decreased CD4+ cell counts in the blood (P = 0.006). Since maximally 1% of CD4+ lymphocytes are infected with HIV, T cell dysfunction and T cell depletion in HIV-infected patients may also be caused by the release of free gp120 that binds to uninfected CD4+ cells. Our data suggest that the functional inhibition and subsequent elimination of uninfected CD4+ lymphocytes with surface gp120-immunoglobulin-complement complexes may be a pathomechanism in the manifestation of AIDS.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1374580, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1386485, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1531308, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1642003, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1654144, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1676283, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1690832, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1698863, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1701946, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1705767, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1713692, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1733629, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1735193, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1870202, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1874921, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1890410, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1892596, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1896455, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1896637, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1899141, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1900576, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1905933, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1931235, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1979339, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1981834, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1983967, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1986308, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1991970, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1993748, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-1994578, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2040625, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2123011, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2251501, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2252640, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2258607, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2282991, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2433466, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2562362, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2575824, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2635886, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2784732, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2865493, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2874661, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-2905892, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-3037522, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-3146262, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-3146263, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-3515644, http://linkedlifedata.com/resource/pubmed/commentcorrection/8102328-8095360
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
152-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Association of T cell and macrophage dysfunction with surface gp 120-immunoglobulin-complement complexes in HIV-infected patients.
pubmed:affiliation
Department of Transplantation Immunology, University of Heidelberg, Germany.
pubmed:publicationType
Journal Article