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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-9-15
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pubmed:abstractText |
Viral superantigens (SAg) were shown in mice to induce anergy and deletion of T cells bearing specific T cell receptor V beta subsets, these perturbations being mainly restricted to CD4+ T cells. In accordance with this model, a putative HIV-associated SAg could contribute to the pathogenesis of HIV-1 infection and AIDS. To reveal the presence of this putative molecule, three study protocols were designed that relied on the fact that similarity of the expressed V beta repertoire of a given pair of individuals is proportional to the relative likeness of their MHC background: (1) by using a quantitative PCR technique that allows simultaneous typing of 24 V beta families, the V beta repertoires of HIV-discordant monozygotic twins were compared; (2) the V beta repertoire found in lymph nodes of HIV-infected subjects was contrasted to that found in peripheral blood of the same individuals; (3) the V beta repertoire of a cohort of HIV-infected mothers was compared with that of their HIV-infected and uninfected children. Results from these approaches revealed that significant perturbations of the TCR V beta repertoire were taking place in HIV-infected subjects, and that these alterations were restricted to T cells expressing specific V beta s. These results are consistent with the presence of an HIV-associated SAg in HIV-1 infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1044-5323
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8102262-Adult,
pubmed-meshheading:8102262-Animals,
pubmed-meshheading:8102262-Antigens, Bacterial,
pubmed-meshheading:8102262-Antigens, Viral,
pubmed-meshheading:8102262-Apoptosis,
pubmed-meshheading:8102262-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8102262-Cohort Studies,
pubmed-meshheading:8102262-Diseases in Twins,
pubmed-meshheading:8102262-Female,
pubmed-meshheading:8102262-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:8102262-HIV Antigens,
pubmed-meshheading:8102262-HIV Infections,
pubmed-meshheading:8102262-HIV-1,
pubmed-meshheading:8102262-HLA-D Antigens,
pubmed-meshheading:8102262-Humans,
pubmed-meshheading:8102262-Immune Tolerance,
pubmed-meshheading:8102262-Infant, Newborn,
pubmed-meshheading:8102262-Leukemia Virus, Murine,
pubmed-meshheading:8102262-Lymph Nodes,
pubmed-meshheading:8102262-Lymphocyte Activation,
pubmed-meshheading:8102262-Mice,
pubmed-meshheading:8102262-Models, Biological,
pubmed-meshheading:8102262-Murine Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8102262-Pregnancy,
pubmed-meshheading:8102262-Pregnancy Complications, Infectious,
pubmed-meshheading:8102262-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8102262-Twins, Monozygotic
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pubmed:year |
1993
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pubmed:articleTitle |
The T cell receptor V beta repertoire in HIV-1 infection and disease.
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pubmed:affiliation |
Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Review
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