rdf:type |
|
lifeskim:mentions |
umls-concept:C0033684,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0041221,
umls-concept:C0041487,
umls-concept:C0079429,
umls-concept:C0086418,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0679058,
umls-concept:C1334043,
umls-concept:C1547699,
umls-concept:C1880022,
umls-concept:C2697616,
umls-concept:C2700640
|
pubmed:issue |
2
|
pubmed:dateCreated |
1993-8-27
|
pubmed:databankReference |
|
pubmed:abstractText |
The complete sequence of a gene encoding a 46-kDa protein of Trypanosoma cruzi is presented. The first ATG complies with the consensus sequence for initiation of translation. A single band of 2 kb was highlighted by hybridizing a probe from the 46-kDa protein gene to a Northern filter containing total T. cruzi RNA. The gene is present in 50-80 copies per cell and most of them are contained in 2 tandem arrays on large T. cruzi chromosomes (> 2000 kb). A strong homology with rat and human tyrosine aminotransferase was detected. Homology with a Trypanosoma brucei retrotransposon was found in the nonsense strand of the intergenic region.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0166-6851
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
59
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
253-62
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8101971-Amino Acid Sequence,
pubmed-meshheading:8101971-Animals,
pubmed-meshheading:8101971-Base Sequence,
pubmed-meshheading:8101971-DNA, Protozoan,
pubmed-meshheading:8101971-Gene Library,
pubmed-meshheading:8101971-Genes, Protozoan,
pubmed-meshheading:8101971-Humans,
pubmed-meshheading:8101971-Molecular Sequence Data,
pubmed-meshheading:8101971-Molecular Weight,
pubmed-meshheading:8101971-Protozoan Proteins,
pubmed-meshheading:8101971-RNA, Protozoan,
pubmed-meshheading:8101971-Rats,
pubmed-meshheading:8101971-Restriction Mapping,
pubmed-meshheading:8101971-Sequence Homology, Amino Acid,
pubmed-meshheading:8101971-Trypanosoma cruzi,
pubmed-meshheading:8101971-Tyrosine Transaminase
|
pubmed:year |
1993
|
pubmed:articleTitle |
Isolation and characterization of a gene from Trypanosoma cruzi encoding a 46-kilodalton protein with homology to human and rat tyrosine aminotransferase.
|
pubmed:affiliation |
Instituto Nacional de Diagnóstico e Investigación de la Enfermedad de Chagas, Ministerio de Salud y Acción Social, Buenos Aires, Argentina.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|