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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8868
|
pubmed:dateCreated |
1993-9-2
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pubmed:abstractText |
A procedure which combines the collection of fetal cells by transcervical flushing and in situ hybridisation techniques on nuclei in interphase was used to detect trisomy 18 in a fetus at 12 weeks of gestation. Using a primed in situ labelling method, we could also detect Y-specific sequences in a small percentage of transcervically flushed cells obtained at 8-12 weeks from pregnant women with male fetuses. This approach seems to be suitable for prenatal diagnosis of major chromosomal abnormalities and other selected inherited disorders very early in gestation.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
|
pubmed:issn |
0140-6736
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
14
|
pubmed:volume |
342
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8101904-Adult,
pubmed-meshheading:8101904-Cervix Uteri,
pubmed-meshheading:8101904-Chromosome Aberrations,
pubmed-meshheading:8101904-Chromosome Disorders,
pubmed-meshheading:8101904-Chromosomes, Human, Pair 18,
pubmed-meshheading:8101904-Female,
pubmed-meshheading:8101904-Fetal Diseases,
pubmed-meshheading:8101904-Humans,
pubmed-meshheading:8101904-In Situ Hybridization,
pubmed-meshheading:8101904-Male,
pubmed-meshheading:8101904-Pregnancy,
pubmed-meshheading:8101904-Prenatal Diagnosis,
pubmed-meshheading:8101904-Therapeutic Irrigation,
pubmed-meshheading:8101904-Trisomy
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pubmed:year |
1993
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pubmed:articleTitle |
Detection of trisomy 18 and Y-derived sequences in fetal nucleated cells obtained by transcervical flushing.
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pubmed:affiliation |
Division of Medical and Molecular Genetics, United Medical School, Guy's Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|