Linked Life Data

8101819

Source:http://linkedlifedata.com/resource/pubmed/id/8101819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-9-1
pubmed:abstractText
Toxin I, a K+ channel blocker found in the venom of the black mamba snake with close sequence homology to the dendrotoxins, produced a concentration-related enhancement of both spontaneous and electrically evoked [3H]noradrenaline ([3H]NA) release from slices of rat cerebral cortex. The effect of toxin I on spontaneous [3H]NA release was blocked by tetrodotoxin and reduced in the presence of either CPP ((+-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid) or CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) and was abolished in the presence of both antagonists. The results suggest that the enhancement of spontaneous [3H]NA release produced by toxin I may be mediated via the release of glutamate acting on both NMDA (N-methyl-D-aspartate) and non-NMDA receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
248
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The effect of toxin I, a K+ channel inhibitor, on [3H]noradrenaline release from rat cerebral cortex.
pubmed:affiliation
Wyeth Research (UK) Ltd., Taplow, Berks, UK.
pubmed:publicationType
Journal Article, In Vitro