Linked Life Data

8101379

Source:http://linkedlifedata.com/resource/pubmed/id/8101379

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-8-19
pubmed:abstractText
Effects of chronic treatment with bevantolol, a beta-adrenoceptor blocker, and of repeated immobilization stress on blood pressure, body weight, and [3H]dihydroalprenolol ([3H]DHA) binding to the cerebral cortex were examined in rats. Systolic blood pressure increased to approximately 150 mmHg when stress was applied for 14 days (2 h day-1). This increase was inhibited by chronic treatment with bevantolol (250 mg kg-1 daily). However, bevantolol did not suppress the inhibition of body weight gain by stress. The maximum number of [3H]DHA binding sites (Bmax) in the cerebral cortex was decreased by stress without changing the affinity, and the decrease in Bmax mainly reflected the reduction of beta 1-adrenoceptors. Bevantolol treatment (250 mg kg-1) increased the Bmax to 137% and completely inhibited the downregulation of beta-adrenoceptors by stress. These results show that bevantolol can inhibit both the hypertension and downregulation of the central beta 1-adrenoceptors induced by stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
623-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of bevantolol HCl on immobilization stress-induced hypertension and central beta-adrenoceptors in rats.
pubmed:affiliation
Department of Pharmacology, Fukui Medical School, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't