| pubmed-article:8100844 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C0598800 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C2350570 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C0039215 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8100844 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8100844 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8100844 | pubmed:dateCreated | 1993-8-12 | lld:pubmed |
| pubmed-article:8100844 | pubmed:abstractText | CD4+ Th cell infiltration into the brain and the activation by cellular elements of the central nervous system (CNS) are thought to be important steps in the initiation of CNS autoimmune diseases. T cell activation requires Ag-specific stimulation and additional costimulatory signals provided by the APC. Here we describe how murine brain microvessel endothelial (En) cells and smooth muscle/pericytes (SM/P) selectively induce the Ag-specific activation of different Th1 and Th2 CD4+ T cell clones. Th1 and Th2 cell clones were used that were specific for the same peptide Ag in the context of the same class II allotype. SM/P preferentially activated Th1 cell clones, whereas En cells activated Th2 cell clones better, as reflected by cell proliferation and production of IL-2 by SM/P-activated Th1 clones and IL-4 by Th2 clones. There was no difference in the level of expression of CD4, CD2, or LFA-1 molecules between these Th cell clones, and anti-CD4, CD2, LFA-1 or ICAM-1 mAb did not differentially affect Ag-induced proliferation among the clones. Moreover, antibody to CD28 did not influence Ag presentation by brain microvessel En or SM/P cells to Ag-specific Th1 and Th2 clones. These results suggest that: 1) different The subsets might require different signals for their activation; 2) different APC might provide different costimulatory signals for Th cell subsets; and 3) brain microvessel En and SM/P might play a differential role in induction of autoreactive T cell responses in the CNS. | lld:pubmed |
| pubmed-article:8100844 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8100844 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100844 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8100844 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8100844 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8100844 | pubmed:author | pubmed-author:HartM NMN | lld:pubmed |
| pubmed-article:8100844 | pubmed:author | pubmed-author:LynchR GRG | lld:pubmed |
| pubmed-article:8100844 | pubmed:author | pubmed-author:SandorMM | lld:pubmed |
| pubmed-article:8100844 | pubmed:author | pubmed-author:FabroPP | lld:pubmed |
| pubmed-article:8100844 | pubmed:author | pubmed-author:WaldschmidtM... | lld:pubmed |
| pubmed-article:8100844 | pubmed:author | pubmed-author:GajewskiT FTF | lld:pubmed |
| pubmed-article:8100844 | pubmed:author | pubmed-author:HerleinJ AJA | lld:pubmed |
| pubmed-article:8100844 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8100844 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8100844 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:8100844 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8100844 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8100844 | pubmed:pagination | 38-47 | lld:pubmed |
| pubmed-article:8100844 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8100844 | pubmed:meshHeading | pubmed-meshheading:8100844-... | lld:pubmed |
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| pubmed-article:8100844 | pubmed:meshHeading | pubmed-meshheading:8100844-... | lld:pubmed |
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| pubmed-article:8100844 | pubmed:meshHeading | pubmed-meshheading:8100844-... | lld:pubmed |
| pubmed-article:8100844 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8100844 | pubmed:articleTitle | Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes. | lld:pubmed |
| pubmed-article:8100844 | pubmed:affiliation | Department of Pathology, University of Iowa College of Medicine, Iowa City 52242. | lld:pubmed |
| pubmed-article:8100844 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8100844 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8100844 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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