Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-8-12
pubmed:abstractText
CD4+ Th cell infiltration into the brain and the activation by cellular elements of the central nervous system (CNS) are thought to be important steps in the initiation of CNS autoimmune diseases. T cell activation requires Ag-specific stimulation and additional costimulatory signals provided by the APC. Here we describe how murine brain microvessel endothelial (En) cells and smooth muscle/pericytes (SM/P) selectively induce the Ag-specific activation of different Th1 and Th2 CD4+ T cell clones. Th1 and Th2 cell clones were used that were specific for the same peptide Ag in the context of the same class II allotype. SM/P preferentially activated Th1 cell clones, whereas En cells activated Th2 cell clones better, as reflected by cell proliferation and production of IL-2 by SM/P-activated Th1 clones and IL-4 by Th2 clones. There was no difference in the level of expression of CD4, CD2, or LFA-1 molecules between these Th cell clones, and anti-CD4, CD2, LFA-1 or ICAM-1 mAb did not differentially affect Ag-induced proliferation among the clones. Moreover, antibody to CD28 did not influence Ag presentation by brain microvessel En or SM/P cells to Ag-specific Th1 and Th2 clones. These results suggest that: 1) different The subsets might require different signals for their activation; 2) different APC might provide different costimulatory signals for Th cell subsets; and 3) brain microvessel En and SM/P might play a differential role in induction of autoreactive T cell responses in the CNS.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-47
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8100844-Animals, pubmed-meshheading:8100844-Antigens, CD, pubmed-meshheading:8100844-Antigens, CD2, pubmed-meshheading:8100844-Antigens, CD28, pubmed-meshheading:8100844-Antigens, CD4, pubmed-meshheading:8100844-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:8100844-Brain, pubmed-meshheading:8100844-CD4-Positive T-Lymphocytes, pubmed-meshheading:8100844-Cell Adhesion Molecules, pubmed-meshheading:8100844-Endothelium, Vascular, pubmed-meshheading:8100844-Female, pubmed-meshheading:8100844-Intercellular Adhesion Molecule-1, pubmed-meshheading:8100844-Interleukin-2, pubmed-meshheading:8100844-Interleukin-4, pubmed-meshheading:8100844-Lymphocyte Activation, pubmed-meshheading:8100844-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:8100844-Mice, pubmed-meshheading:8100844-Mice, Inbred BALB C, pubmed-meshheading:8100844-Muscle, Smooth, pubmed-meshheading:8100844-Receptors, Immunologic, pubmed-meshheading:8100844-T-Lymphocyte Subsets, pubmed-meshheading:8100844-T-Lymphocytes, Helper-Inducer
pubmed:year
1993
pubmed:articleTitle
Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes.
pubmed:affiliation
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.