rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-8-12
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pubmed:abstractText |
CD4+ Th cell infiltration into the brain and the activation by cellular elements of the central nervous system (CNS) are thought to be important steps in the initiation of CNS autoimmune diseases. T cell activation requires Ag-specific stimulation and additional costimulatory signals provided by the APC. Here we describe how murine brain microvessel endothelial (En) cells and smooth muscle/pericytes (SM/P) selectively induce the Ag-specific activation of different Th1 and Th2 CD4+ T cell clones. Th1 and Th2 cell clones were used that were specific for the same peptide Ag in the context of the same class II allotype. SM/P preferentially activated Th1 cell clones, whereas En cells activated Th2 cell clones better, as reflected by cell proliferation and production of IL-2 by SM/P-activated Th1 clones and IL-4 by Th2 clones. There was no difference in the level of expression of CD4, CD2, or LFA-1 molecules between these Th cell clones, and anti-CD4, CD2, LFA-1 or ICAM-1 mAb did not differentially affect Ag-induced proliferation among the clones. Moreover, antibody to CD28 did not influence Ag presentation by brain microvessel En or SM/P cells to Ag-specific Th1 and Th2 clones. These results suggest that: 1) different The subsets might require different signals for their activation; 2) different APC might provide different costimulatory signals for Th cell subsets; and 3) brain microvessel En and SM/P might play a differential role in induction of autoreactive T cell responses in the CNS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-47
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8100844-Animals,
pubmed-meshheading:8100844-Antigens, CD,
pubmed-meshheading:8100844-Antigens, CD2,
pubmed-meshheading:8100844-Antigens, CD28,
pubmed-meshheading:8100844-Antigens, CD4,
pubmed-meshheading:8100844-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:8100844-Brain,
pubmed-meshheading:8100844-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8100844-Cell Adhesion Molecules,
pubmed-meshheading:8100844-Endothelium, Vascular,
pubmed-meshheading:8100844-Female,
pubmed-meshheading:8100844-Intercellular Adhesion Molecule-1,
pubmed-meshheading:8100844-Interleukin-2,
pubmed-meshheading:8100844-Interleukin-4,
pubmed-meshheading:8100844-Lymphocyte Activation,
pubmed-meshheading:8100844-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:8100844-Mice,
pubmed-meshheading:8100844-Mice, Inbred BALB C,
pubmed-meshheading:8100844-Muscle, Smooth,
pubmed-meshheading:8100844-Receptors, Immunologic,
pubmed-meshheading:8100844-T-Lymphocyte Subsets,
pubmed-meshheading:8100844-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1993
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pubmed:articleTitle |
Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes.
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pubmed:affiliation |
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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