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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1993-7-30
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pubmed:abstractText |
We have shown recently that normal human mammary epithelial cells do produce interleukin 6 (IL6), interleukin 8, and a nonsecreted form of tumor necrosis factor. Here we report that ductal infiltrating mammary carcinomas fail to express immunoreactive IL6. Since abnormalities of cytokine genes are a frequent event in cancer, we investigated the production of and the response to cytokines of mammary cells using a panel of oncogene-transformed cells derived from the spontaneously immortalized MCF-10A cell line. We found that only the parental line and the int-2-transformed cells responded to exogenous IL6 and/or were suppressed by IL6-neutralizing antibody. In contrast to highly transformed cells, these two lines, which were either nontransformed (MCF-10A) or weakly transformed (int-2), were found to express IL6 receptors. These data suggest that loss of IL6 pathways can be a marker of mammary cell transformation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/FGF3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fgf3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 3,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
53
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pubmed:geneSymbol |
c-Ha-ras,
c-erb-B2,
int-2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2957-60
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8100482-Animals,
pubmed-meshheading:8100482-Breast,
pubmed-meshheading:8100482-Breast Neoplasms,
pubmed-meshheading:8100482-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:8100482-Cell Division,
pubmed-meshheading:8100482-Cytokines,
pubmed-meshheading:8100482-Epithelium,
pubmed-meshheading:8100482-Fibroblast Growth Factor 3,
pubmed-meshheading:8100482-Fibroblast Growth Factors,
pubmed-meshheading:8100482-Genes, ras,
pubmed-meshheading:8100482-Humans,
pubmed-meshheading:8100482-Immunohistochemistry,
pubmed-meshheading:8100482-Interleukin-6,
pubmed-meshheading:8100482-Interleukin-8,
pubmed-meshheading:8100482-Mice,
pubmed-meshheading:8100482-Proto-Oncogene Proteins,
pubmed-meshheading:8100482-Receptor, erbB-2,
pubmed-meshheading:8100482-Stimulation, Chemical,
pubmed-meshheading:8100482-Transfection,
pubmed-meshheading:8100482-Tumor Cells, Cultured
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pubmed:year |
1993
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pubmed:articleTitle |
Growth-stimulating activity of interleukin 6 on human mammary epithelial cells transfected with the int-2 gene.
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pubmed:affiliation |
Institute of Pathological Anatomy, University of Pisa Medical School, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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