| pubmed-article:8100269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
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| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0043046 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0108790 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0348011 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8100269 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:8100269 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8100269 | pubmed:dateCreated | 1993-7-23 | lld:pubmed |
| pubmed-article:8100269 | pubmed:abstractText | Purified CD4+ lymph node T cells were sorted into two populations on the basis of their expression of CD45RB (CD45RBhi and CD45RBlo) and injected into congenic severe combined immunodeficient (SCID) mice. After a period of time that was dependent on the number of cells injected, the SCID mice that received CD45RBhi/CD4+ T cells developed a wasting disease that was not seen in SCID mice that received the CD4+/CD45RBlo cells or whole lymph node cells. At death, SCID mice that received the CD4+/CD45RBhi cells had increased spleen and lymph node cellularity compared with normal SCID mice and SCID mice that received the CD4+/CD45RBlo T cells. The spleen and lymph node contained CD4+ cells and neither CD8+ nor surface immunoglobulin M-positive cells, plus a population of cells that did not express any of those markers. At necropsy, the SCID mice that received the CD4+/CD45RBhi cells had significant hyperplasia of the intestinal mucosa with significant lymphoid cell accumulation in the lamina propria. Interestingly, mice that received mixtures of whole lymph node or purified CD4+ cells with CD4+/CD45RBhi cells did not develop weight loss, indicating that the unseparated CD4+ population contained cells that were capable of regulating the reactivity of the CD4+/CD45RBhi cells. | lld:pubmed |
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| pubmed-article:8100269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8100269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100269 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8100269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8100269 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8100269 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8100269 | pubmed:author | pubmed-author:WatsonJ DJD | lld:pubmed |
| pubmed-article:8100269 | pubmed:author | pubmed-author:LiggittDD | lld:pubmed |
| pubmed-article:8100269 | pubmed:author | pubmed-author:BradenGG | lld:pubmed |
| pubmed-article:8100269 | pubmed:author | pubmed-author:MorrisseyP... | lld:pubmed |
| pubmed-article:8100269 | pubmed:author | pubmed-author:CharrierKK | lld:pubmed |
| pubmed-article:8100269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8100269 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8100269 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:8100269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8100269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8100269 | pubmed:pagination | 237-44 | lld:pubmed |
| pubmed-article:8100269 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8100269 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8100269 | pubmed:articleTitle | CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells. | lld:pubmed |
| pubmed-article:8100269 | pubmed:affiliation | Department of Immunology, Immunex Research and Development Corp., Seattle, Washington 98101. | lld:pubmed |
| pubmed-article:8100269 | pubmed:publicationType | Journal Article | lld:pubmed |
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