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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0017262,
umls-concept:C0039194,
umls-concept:C0043046,
umls-concept:C0085112,
umls-concept:C0108790,
umls-concept:C0205263,
umls-concept:C0348011,
umls-concept:C0441889,
umls-concept:C1171362,
umls-concept:C1332714,
umls-concept:C1515670,
umls-concept:C1527148,
umls-concept:C1705822,
umls-concept:C1998793
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pubmed:issue |
1
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pubmed:dateCreated |
1993-7-23
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pubmed:abstractText |
Purified CD4+ lymph node T cells were sorted into two populations on the basis of their expression of CD45RB (CD45RBhi and CD45RBlo) and injected into congenic severe combined immunodeficient (SCID) mice. After a period of time that was dependent on the number of cells injected, the SCID mice that received CD45RBhi/CD4+ T cells developed a wasting disease that was not seen in SCID mice that received the CD4+/CD45RBlo cells or whole lymph node cells. At death, SCID mice that received the CD4+/CD45RBhi cells had increased spleen and lymph node cellularity compared with normal SCID mice and SCID mice that received the CD4+/CD45RBlo T cells. The spleen and lymph node contained CD4+ cells and neither CD8+ nor surface immunoglobulin M-positive cells, plus a population of cells that did not express any of those markers. At necropsy, the SCID mice that received the CD4+/CD45RBhi cells had significant hyperplasia of the intestinal mucosa with significant lymphoid cell accumulation in the lamina propria. Interestingly, mice that received mixtures of whole lymph node or purified CD4+ cells with CD4+/CD45RBhi cells did not develop weight loss, indicating that the unseparated CD4+ population contained cells that were capable of regulating the reactivity of the CD4+/CD45RBhi cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-1541419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-1684782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-1690660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-1832321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-1851798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-1970350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-1971173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2138068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2141628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2205920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2217193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2258700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2413363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2475124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2523954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2528147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-2908229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-3106474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-3275717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-3280724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-3281611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-3486193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-3490534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-3496416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-418341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-6165588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-6168690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-6226585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-664189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-6823332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100269-6983558
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1993
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pubmed:articleTitle |
CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.
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pubmed:affiliation |
Department of Immunology, Immunex Research and Development Corp., Seattle, Washington 98101.
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pubmed:publicationType |
Journal Article
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