Linked Life Data

8099570

Source:http://linkedlifedata.com/resource/pubmed/id/8099570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-7-9
pubmed:abstractText
In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the tumor and patient characteristics showed that a pre-selection had taken place for small tumors. Eighty percent of the tumors were classified as stage pT1 or pT2 tumors. This small tumor size and the large size of the tumor sections used for autoradiography can explain the high incidence of somatostatin expression in our series. Forty-three of these tumors, 30 SSR-positive and 13 SSR-negative, were tested for morphological and (immuno)histochemical markers of neuroendocrine differentiation. Three SSR-positive tumors were also positive for 2 or more other markers of neuroendocrine differentiation, suggesting that neuroendocrine breast tumors and SSR-positive breast tumors are overlapping, but independent, subgroups of tumors. To test whether specific genetic alterations are associated with SSR-positive or SSR-negative breast tumors, we examined in a selected series of 47 SSR-positive and 32 SSR-negative breast tumors a number of known genetic markers by Southern blotting. Deletions or rearrangements of the retinoblastoma (RB) tumor-suppressor gene were observed in 5 SSR-positive and 5 SSR-negative tumors. In 4 SSR-positive and also in 4 SSR-negative tumors an amplification of the neu oncogene was observed. Amplifications of the int-2 oncogene were found in 2 SSR-positive and 1 SSR-negative breast tumor. In one SSR-positive tumor an amplification of the c-myc oncogene was observed and in another SSR-positive tumor a rearrangement of the L-myc oncogene was found.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
54
pubmed:geneSymbol
L-myc, N-myc, c-myc, int-2, neu
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
357-62
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:8099570-Autoradiography, pubmed-meshheading:8099570-Blotting, Southern, pubmed-meshheading:8099570-Breast Neoplasms, pubmed-meshheading:8099570-Cell Differentiation, pubmed-meshheading:8099570-Female, pubmed-meshheading:8099570-Fibroblast Growth Factor 3, pubmed-meshheading:8099570-Fibroblast Growth Factors, pubmed-meshheading:8099570-Gene Amplification, pubmed-meshheading:8099570-Genes, Retinoblastoma, pubmed-meshheading:8099570-Genes, myc, pubmed-meshheading:8099570-Genetic Markers, pubmed-meshheading:8099570-Humans, pubmed-meshheading:8099570-Middle Aged, pubmed-meshheading:8099570-Neurosecretory Systems, pubmed-meshheading:8099570-Protein Kinases, pubmed-meshheading:8099570-Proto-Oncogene Proteins, pubmed-meshheading:8099570-Receptor, erbB-2, pubmed-meshheading:8099570-Receptors, Somatostatin, pubmed-meshheading:8099570-Tumor Markers, Biological
pubmed:year
1993
pubmed:articleTitle
Somatostatin receptor-positive primary breast tumors: genetic, patient and tumor characteristics.
pubmed:affiliation
Dept of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't