Linked Life Data

8097972

Source:http://linkedlifedata.com/resource/pubmed/id/8097972

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-6-10
pubmed:abstractText
There is a delay from the time when amacrine cells are generated to the time when the dopaminergic phenotype is first expressed, in the chick retina. In order to determine the birthdate of amacrine cells expressing the tyrosine hydroxylase (TH) phenotype, we combined autoradiography of [3H]thymidine incorporated into dividing cells with the immunocytochemical method for TH in mature retinas. We also investigated the morphogenesis and the topographical distribution of dopaminergic amacrine cells using radial and horizontal sections of the chick retina. Although TH immunoreactivity was first detected at E12, the morphological pattern of TH-immunoreactive (TH-IR) amacrine cells started to be defined at E16, with an increasing arborization complexity until hatching. The topographical distribution of dopaminergic cells revealed that TH-IR neurons were predominantly concentrated in the dorsal retina of E13 and E14 embryos. At E18 and PH2 the distribution of dopaminergic cells was uniform throughout the retina. Autoradiography of [3H]thymidine incorporated association with TH immunocytochemistry showed that dopaminergic amacrine cells are generated during a discrete period (E3 through E7) of amacrinogenesis that occurs from E3 to E9. Therefore, a delay of days between histogenesis of dopaminergic amacrine cells and their differentiation is observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
226-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Histogenesis and topographical distribution of tyrosine hydroxylase immunoreactive amacrine cells in the developing chick retina.
pubmed:affiliation
Depto. de Farmacologia e Psicobiologia, Universidade do Estado do Rio de Janeiro, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't