Linked Life Data

8097614

Source:http://linkedlifedata.com/resource/pubmed/id/8097614

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1993-5-24
pubmed:abstractText
To determine the effect of thrombolytic therapy on the frequency of right ventricular (RV) dysfunction, and whether RV dysfunction is a risk factor for morbidity and mortality after discharge from the hospital, 1,110 patients in the Thrombolysis in Myocardial Infarction (TIMI) II trial with acute inferior wall left ventricular myocardial infarction were studied. RV dysfunction was defined as an RV wall motion abnormality on equilibrium radionuclide ventriculography performed a mean of 9 days after admission to the hospital. Fifty-eight patients (5%) had RV dysfunction. Baseline clinical characteristics among patients with and without RV dysfunction were similar. However, patients with RV dysfunction had a lower mean left ventricular ejection fraction (51.2 +/- 1.2% vs 55.5 +/- 0.3%; p < 0.001) and a greater frequency of in-hospital complications. Angiographic data from patients undergoing protocol catheterization 18 to 48 hours after hospital admission show that the infarct-related artery was more likely to be occluded in those with RV dysfunction (48% [15 of 31] vs 14% [68 of 495]; p < 0.001). There was no difference in the frequency of multivessel disease between the 2 groups. In patients with RV dysfunction in whom radionuclide ventriculography was repeated 6 weeks after hospital discharge, RV wall motion abnormalities persisted in only 18% (8 of 45). Mortality in the year after discharge was 3.5% (2 of 58) among patients with RV dysfunction compared with 1.7% (18 of 1,052; p = NS) among those without RV dysfunction.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1148-52
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:8097614-Adrenergic beta-Antagonists, pubmed-meshheading:8097614-Angioplasty, Balloon, Coronary, pubmed-meshheading:8097614-Combined Modality Therapy, pubmed-meshheading:8097614-Constriction, Pathologic, pubmed-meshheading:8097614-Coronary Vessels, pubmed-meshheading:8097614-Female, pubmed-meshheading:8097614-Heart Diseases, pubmed-meshheading:8097614-Heart Ventricles, pubmed-meshheading:8097614-Humans, pubmed-meshheading:8097614-Male, pubmed-meshheading:8097614-Middle Aged, pubmed-meshheading:8097614-Myocardial Infarction, pubmed-meshheading:8097614-Radionuclide Ventriculography, pubmed-meshheading:8097614-Thrombolytic Therapy, pubmed-meshheading:8097614-Tissue Plasminogen Activator, pubmed-meshheading:8097614-Ventricular Function, Left, pubmed-meshheading:8097614-Ventricular Function, Right
pubmed:year
1993
pubmed:articleTitle
Frequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the thrombolysis in myocardial infarction [TIMI] II trial). The TIMI Research Group.
pubmed:affiliation
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55902.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial