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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-5-25
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pubmed:abstractText |
Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I- and double-deficient mice provides data challenging it. There exists a significant population of CD4 single positive cells in class II-deficient animals that is intermediate in maturity between CD4+CD8+ and end-stage CD4+CD8- thymocytes and is selected on class I molecules; an equivalent CD8+CD4- population occurs in class I-deficient animals. We propose a selective model entailing two TCR-MHC molecule engagements: the first provokes random down-modulation of either CD4 or CD8 and a degree of differentiation; the second, requiring participation of the appropriate coreceptor, permits end-stage differentiation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Nucleotidylexotransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
73
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pubmed:geneSymbol |
RAG-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8097430-Animals,
pubmed-meshheading:8097430-Antigens, CD8,
pubmed-meshheading:8097430-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:8097430-Base Sequence,
pubmed-meshheading:8097430-Bromodeoxyuridine,
pubmed-meshheading:8097430-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8097430-Cell Differentiation,
pubmed-meshheading:8097430-Cell Division,
pubmed-meshheading:8097430-DNA,
pubmed-meshheading:8097430-DNA Nucleotidylexotransferase,
pubmed-meshheading:8097430-Flow Cytometry,
pubmed-meshheading:8097430-Histocompatibility Antigens Class I,
pubmed-meshheading:8097430-Histocompatibility Antigens Class II,
pubmed-meshheading:8097430-Homeodomain Proteins,
pubmed-meshheading:8097430-Ionomycin,
pubmed-meshheading:8097430-Mice,
pubmed-meshheading:8097430-Mice, Mutant Strains,
pubmed-meshheading:8097430-Molecular Sequence Data,
pubmed-meshheading:8097430-Oligodeoxyribonucleotides,
pubmed-meshheading:8097430-Proteins,
pubmed-meshheading:8097430-Receptors, Antigen, T-Cell,
pubmed-meshheading:8097430-T-Lymphocyte Subsets,
pubmed-meshheading:8097430-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8097430-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:8097430-Tetradecanoylphorbol Acetate,
pubmed-meshheading:8097430-Thymus Gland
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pubmed:year |
1993
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pubmed:articleTitle |
Another view of the selective model of thymocyte selection.
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pubmed:affiliation |
Laboratoire de Génétique Moléculaire, Eucaryotes du Centre National de la Recherche Scientifique, Faculté de Médecine, Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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