Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1993-5-17
pubmed:abstractText
To compare the ability of different cytokines and other molecules to enhance the immunogenicity of tumor cells, we generated 10 retroviruses encoding potential immunomodulators and studied the vaccination properties of murine tumor cells transduced by the viruses. Using a B16 melanoma model, in which irradiated tumor cells alone do not stimulate significant anti-tumor immunity, we found that irradiated tumor cells expressing murine granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulated potent, long-lasting, and specific anti-tumor immunity, requiring both CD4+ and CD8+ cells. Irradiated cells expressing interleukins 4 and 6 also stimulated detectable, but weaker, activity. In contrast to the B16 system, we found that in a number of other tumor models, the levels of anti-tumor immunity reported previously in cytokine gene transfer studies involving live, transduced cells could be achieved through the use of irradiated cells alone. Nevertheless, manipulation of the vaccine or challenge doses made it possible to demonstrate the activity of murine GM-CSF in those systems as well. Overall, our results have important implications for the clinical use of genetically modified tumor cells as therapeutic cancer vaccines.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-1109790, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-13502695, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-13756652, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-1570303, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-1617640, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-1683890, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-1706752, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-1910679, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-1948050, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2016545, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2022919, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2023898, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2038321, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2123742, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2137200, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2137372, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2212951, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2274062, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2512580, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2573511, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2785856, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2834728, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-2981916, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3083412, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3133208, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3257775, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3262872, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3413107, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3782794, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3856324, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3874057, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-3918306, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-6159417, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-6310596, http://linkedlifedata.com/resource/pubmed/commentcorrection/8097319-6415170
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3539-43
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8097319-Animals, pubmed-meshheading:8097319-Antibodies, Monoclonal, pubmed-meshheading:8097319-Antigens, CD4, pubmed-meshheading:8097319-Antigens, CD8, pubmed-meshheading:8097319-Carcinoma, Renal Cell, pubmed-meshheading:8097319-Cell Adhesion Molecules, pubmed-meshheading:8097319-Colonic Neoplasms, pubmed-meshheading:8097319-Female, pubmed-meshheading:8097319-Fibrosarcoma, pubmed-meshheading:8097319-Genetic Vectors, pubmed-meshheading:8097319-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:8097319-Immunization, pubmed-meshheading:8097319-Intercellular Adhesion Molecule-1, pubmed-meshheading:8097319-Kidney Neoplasms, pubmed-meshheading:8097319-Lung Neoplasms, pubmed-meshheading:8097319-Lymphocyte Depletion, pubmed-meshheading:8097319-Melanoma, Experimental, pubmed-meshheading:8097319-Mice, pubmed-meshheading:8097319-Mice, Inbred BALB C, pubmed-meshheading:8097319-Mice, Inbred C57BL, pubmed-meshheading:8097319-Retroviridae, pubmed-meshheading:8097319-T-Lymphocyte Subsets, pubmed-meshheading:8097319-Transfection, pubmed-meshheading:8097319-Tumor Cells, Cultured
pubmed:year
1993
More...