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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-5-20
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pubmed:abstractText |
X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1351869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1374165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-13743326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1427881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-14451053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1554497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1711085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1729687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1746558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1757090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1863997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1897522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1923839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-1980111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-2081601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-2316523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-2676386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-2883112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-2888720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-3080678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-3684611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8097258-6328976
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2593
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
202-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8097258-Base Sequence,
pubmed-meshheading:8097258-Blotting, Southern,
pubmed-meshheading:8097258-Chromosome Mapping,
pubmed-meshheading:8097258-DNA, Single-Stranded,
pubmed-meshheading:8097258-Female,
pubmed-meshheading:8097258-Genetic Linkage,
pubmed-meshheading:8097258-Genetic Markers,
pubmed-meshheading:8097258-Humans,
pubmed-meshheading:8097258-Hypergammaglobulinemia,
pubmed-meshheading:8097258-Immunoglobulin M,
pubmed-meshheading:8097258-Lod Score,
pubmed-meshheading:8097258-Male,
pubmed-meshheading:8097258-Molecular Sequence Data,
pubmed-meshheading:8097258-Oligonucleotide Probes,
pubmed-meshheading:8097258-Pedigree,
pubmed-meshheading:8097258-Polymerase Chain Reaction,
pubmed-meshheading:8097258-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:8097258-Syndrome,
pubmed-meshheading:8097258-X Chromosome
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pubmed:year |
1993
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pubmed:articleTitle |
Mapping of the X linked form of hyper IgM syndrome (HIGM1)
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pubmed:affiliation |
Molecular Genetics Unit, Institute of Child Health, London.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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