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rdf:type |
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205263,
umls-concept:C0206527,
umls-concept:C0221117,
umls-concept:C0521009,
umls-concept:C0591833,
umls-concept:C0871261,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1533691,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C1879547,
umls-concept:C2349975,
umls-concept:C2603343,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
1993-5-20
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pubmed:abstractText |
Primary and secondary responses of murine CD4+ T cells and CD8+ T cells upon stimulation with staphylococcal enterotoxin E (SEE) bearing superantigenic properties were examined. Both isolated C57BL/6 splenic CD4+ T cells and CD8+ T cells proliferated and produced IL-2 and IFN-gamma upon stimulation with SEE in substantial levels. The amounts of IL-2 were greater in CD4+ T cells and those of IFN-gamma were somewhat greater in CD8+ T cells. SEE-induced CD4+ T lymphoblasts, larger parts of which bore the V beta 11 element in their TCR, proliferated, produced IL-2 and IFN-gamma, and showed toxin-dependent cytotoxicity in substantial levels upon restimulation with SEE. By contrast, SEE-induced CD8+ T lymphoblasts, the larger part of which bore the V beta 11 element, did not show the first two of the three responses at all upon restimulation with SEE, whereas these cells showed greater cytotoxicity. The CD8+ T lymphoblasts did not suppress the reactivity of the CD4+ T lymphoblasts. Both SEE-induced CD4+ T lymphoblasts and CD8+ T lymphoblasts proliferated and produced IL-2 and IFN-gamma in comparable levels upon stimulation with rIL-2 or mAb to CD3 or V beta 11.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor-CD3 Complex, Antigen...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin E, Staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3873-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8097227-Animals,
pubmed-meshheading:8097227-Antigens, Bacterial,
pubmed-meshheading:8097227-Antigens, CD8,
pubmed-meshheading:8097227-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8097227-Cytotoxicity, Immunologic,
pubmed-meshheading:8097227-Enterotoxins,
pubmed-meshheading:8097227-Female,
pubmed-meshheading:8097227-Immune Tolerance,
pubmed-meshheading:8097227-Interleukin-2,
pubmed-meshheading:8097227-Lymphocyte Activation,
pubmed-meshheading:8097227-Male,
pubmed-meshheading:8097227-Mice,
pubmed-meshheading:8097227-Mice, Inbred C57BL,
pubmed-meshheading:8097227-Receptor-CD3 Complex, Antigen, T-Cell,
pubmed-meshheading:8097227-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8097227-Staphylococcus aureus,
pubmed-meshheading:8097227-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Study of activation of murine T cells with bacterial superantigens. In vitro induction of enhanced responses in CD4+ T cells and of anergy in CD8+ T cells.
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pubmed:affiliation |
Department of Microbiology and Immunology, Tokyo Women's Medical College, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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