Linked Life Data

8097055

Source:http://linkedlifedata.com/resource/pubmed/id/8097055

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-5-11
pubmed:abstractText
This study was performed to confirm the usefulness of 12 mg nipradilol, a beta-blocker with a vasodilator action similar to that of nitrate-type drugs, in the treatment of effort angina pectoris. It also discusses the mechanism of the action of this drug when using the exercise test heart rate-ST displacement analysis. The symptom threshold multistage graded exercise test was performed using nine patients with chronic stabilized effort angina pectoris after an observation period and an 8-week administration period and HR-ST analysis was performed simultaneously. The number of anginal attacks significantly decreased from the 2nd week, and the heart rate at rest decreased significantly in the prone position although blood pressure did not change. The maximum oxygen intake increased markedly from 13.7 +/- 1.1 ml/kg/min to 19.3 +/- 2.5 ml/kg/min, and the maximum ST decrease improved significantly from 1.72 +/- 0.45 mm to 1.17 +/- 0.19mm. In HR-ST analysis, delta ST/delta HR and delta ST/delta DP tended to improve slightly. Since monotherapy with a beta-blocker causes significant increase in delta ST/delta HR and delta ST/delta DP, it was assumed that a vasodilator action in addition to a beta-blocker action is involved in the improvement of maximum ST decrease brought about by nipradilol.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0452-3458
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Effects of nipradilol on the patients of angina pectoris: results from the study of the exercise electrocardiography using HR-ST loop method].
pubmed:affiliation
First Department of Internal Medicine, Tohoku University School of Medicine.
pubmed:publicationType
Journal Article, English Abstract