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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-5-13
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pubmed:abstractText |
Application of a GABAA (gamma-aminobutyric acid-A) receptor antagonist through a microdialysis probe into the forelimb primary motor cortex of ketamine-anesthetized rats induced electromyographic activity in the contralateral forelimb. This activity consisted of spontaneous forelimb movements with a frequency of 0.8 +/- 0.2 Hz. The motor activity induced by GABAA receptor blockade was suppressed by application through the dialysis probe of a non-NMDA (N-methyl-D-aspartate) receptor antagonist, but not by an NMDA receptor antagonist. Glutamate eliminated the blocking effect of the non-NMDA receptor antagonist upon GABAA receptor blockade mediated activity. In conclusion, the results show that an excitatory input to the motor cortical output is mediated through a non-NMDA receptor, therefore the effects of cortical disinhibition may be controlled by non-NMDA receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3940
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
150
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|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8097030-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:8097030-Animals,
pubmed-meshheading:8097030-Bicuculline,
pubmed-meshheading:8097030-Brain Mapping,
pubmed-meshheading:8097030-Dialysis,
pubmed-meshheading:8097030-Electromyography,
pubmed-meshheading:8097030-GABA-A Receptor Antagonists,
pubmed-meshheading:8097030-Male,
pubmed-meshheading:8097030-Models, Neurological,
pubmed-meshheading:8097030-Motor Activity,
pubmed-meshheading:8097030-Motor Cortex,
pubmed-meshheading:8097030-Peripheral Nerves,
pubmed-meshheading:8097030-Quinoxalines,
pubmed-meshheading:8097030-Rats,
pubmed-meshheading:8097030-Rats, Wistar,
pubmed-meshheading:8097030-Receptors, GABA-A,
pubmed-meshheading:8097030-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
1993
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pubmed:articleTitle |
Motor activity induced by disinhibition of the primary motor cortex of the rat is blocked by a non-NMDA glutamate receptor antagonist.
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pubmed:affiliation |
Cajal Institute, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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