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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1993-5-13
|
| pubmed:databankReference | |
| pubmed:abstractText |
The Bacillus subtilis flhA gene lies in the major che/fla operon, a transcription unit that spans 26 kilobases (kb) of DNA. flhA encodes a 677-amino-acid polypeptide that is a strong candidate for an integral membrane protein. The sequence of FlhA displays substantial homology to a newly identified family of putative signal-transducing receptors that have been implicated in diverse cellular processes. FlhA is the first member of this family to be described from a Gram-positive bacterium. We demonstrate that flhA is a flagellar gene and that FlhA is required in trans for the formation of products from some, but not all, B. subtilis motility-related operons that are regulated by the sigma D form of RNA polymerase. We suggest that FlhA is a component of a signalling system that is involved with the formation of some flagellar gene products during the biosynthesis of the flagellum.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0950-382X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:geneSymbol |
fla,
flhA
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
735-43
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8097015-Amino Acid Sequence,
pubmed-meshheading:8097015-Bacillus subtilis,
pubmed-meshheading:8097015-Bacterial Proteins,
pubmed-meshheading:8097015-Base Sequence,
pubmed-meshheading:8097015-Cell Movement,
pubmed-meshheading:8097015-Fimbriae, Bacterial,
pubmed-meshheading:8097015-Gene Expression Regulation, Bacterial,
pubmed-meshheading:8097015-Genes, Bacterial,
pubmed-meshheading:8097015-Membrane Proteins,
pubmed-meshheading:8097015-Molecular Sequence Data,
pubmed-meshheading:8097015-Multigene Family,
pubmed-meshheading:8097015-Mutagenesis, Site-Directed,
pubmed-meshheading:8097015-Operon,
pubmed-meshheading:8097015-Recombinant Fusion Proteins,
pubmed-meshheading:8097015-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:8097015-Sequence Alignment,
pubmed-meshheading:8097015-Sequence Homology, Amino Acid,
pubmed-meshheading:8097015-Signal Transduction
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Bacillus subtilis FlhA: a flagellar protein related to a new family of signal-transducing receptors.
|
| pubmed:affiliation |
Department of Biochemistry, College of Medicine, University of Illinois, Urbana 61801.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|