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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1993-4-22
|
| pubmed:databankReference | |
| pubmed:abstractText |
A 14-kilobase pair (kb) region of genomic DNA encoding the human neuropeptide Y Y1-receptor gene including 3'- and 5'-flanking sequences has been cloned and the human gene localized to chromosome 4q(31.3-32). In contrast to the contiguous structure of most G protein-coupled receptor genes, the NPY Y1 receptor gene is divided into three exons. A small 5'-exon of the mRNA untranslated region is separated by a 6-kb intron from the second exon. The coding region of the receptor is interrupted by a small intron, containing an in-frame stop codon, shortly after the proposed fifth transmembrane domain. In the 5'-flanking region a potential cAMP-response element and an AP-2 site, in addition to a TATA-like sequence and a typical CAAT, box are present. A single point mutation within the 6-kb intron generates a PstI polymorphic site with a highly informative allele frequency of 54:46% in the population.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
268
|
| pubmed:geneSymbol |
NPY Y1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6703-7
|
| pubmed:dateRevised |
2008-8-29
|
| pubmed:meshHeading |
pubmed-meshheading:8095935-Alleles,
pubmed-meshheading:8095935-Amino Acid Sequence,
pubmed-meshheading:8095935-Base Sequence,
pubmed-meshheading:8095935-Blotting, Southern,
pubmed-meshheading:8095935-Cells, Cultured,
pubmed-meshheading:8095935-Chromosomes, Human, Pair 4,
pubmed-meshheading:8095935-Cloning, Molecular,
pubmed-meshheading:8095935-DNA,
pubmed-meshheading:8095935-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:8095935-Exons,
pubmed-meshheading:8095935-Gene Expression Regulation,
pubmed-meshheading:8095935-Humans,
pubmed-meshheading:8095935-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8095935-Introns,
pubmed-meshheading:8095935-Molecular Sequence Data,
pubmed-meshheading:8095935-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:8095935-Receptors, Neuropeptide Y,
pubmed-meshheading:8095935-Restriction Mapping,
pubmed-meshheading:8095935-Transcription, Genetic
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.
|
| pubmed:affiliation |
Garvan Institute of Medical Research, St. Vincent's Hospital Darlinghurst, Sydney, New South Wales, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|