Linked Life Data

8095152

Source:http://linkedlifedata.com/resource/pubmed/id/8095152

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1993-4-8
pubmed:abstractText
Homeotic genes are responsible for determining the identity of body structures along the anterior-posterior axis. In Drosophila the early patterning system defines the differential expression pattern of the homeotic genes. In laterstages the Polycomb-group (Pc-G) genes were found to keep homeotic genes stably repressed in those domains where they have to be inactive. At the molecular level the Pc-G is supposed to exert its repressory role by influencing the higher order structure of chromatin. Here we show that during oogenesis the Polycomb (Pc) protein is localized in the polytene nuclei of the nurse cells. In addition, in late stages we observe overlapping gradients of expression in the somatic follicle cells, suggesting also an important function of Pc on the determinants involved in egg formation. During embryogenesis Pc is found in all tissues, though in later stages it preferentially accumulates in the CNS. Interestingly, we have identified a feedback-type regulation: the Ultrabithorax gene, a homeotic target gene of Pc, in its own domain of expression is down-regulating Pc.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:geneSymbol
Pc, Polycomb
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-46
pubmed:dateRevised
2008-10-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The Polycomb gene is differentially regulated during oogenesis and embryogenesis of Drosophila melanogaster.
pubmed:affiliation
ZMBH Universität Heidelberg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't