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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-3-24
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pubmed:abstractText |
It has been shown that T-cell receptor (TcR) gamma delta + CD4- CD8- T cells increase in number and have an important role in early protection in murine Listeria monocytogenes infection. In this report, to characterize further the phenotype of the gamma delta T cells in listeriosis, we analysed V region gene usage and in vitro antigen recognition of the TcR gamma delta T cells in the peritoneal cavity of mice at the early phase after i.p. infection with a sublethal dose of L. monocytogenes. The gamma delta T cells predominantly expressed V delta 6 which has been reported to be expressed by TcR gamma delta-bearing foetal thymocyte hybridomas specific to mycobacterial and self heat-shock protein (hsp) 60. These early appearing CD3+ CD4- CD8- T cells in Listeria-infected mice, which were reported to be TcR gamma delta T cells, increased in proportion and in size by in vitro stimulation with recombinant hsp 60 from Mycobacterium bovis and purified protein derivative from M. tuberculosis but not by stimulation with heat-killed L. monocytogenes. A 65,000 MW molecule was detected in the lysate of viable L. monocytogenes but not in the lysate of heat-killed L. monocytogenes by a monoclonal antibody (mAb) raised against mycobacterial hsp 60. These results suggest that the V delta 6-bearing peripheral gamma delta T cells are activated by recognizing listerial hsp 60 expressed by viable L. monocytogenes. The hsp 60-reactive V delta 6-bearing T cells may have an important role in protection against L. monocytogenes and other parasites that express hsp 60 at high level.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-1345917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-1695022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-1978758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2106682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2108043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2145851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2379238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2467936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2473405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2477705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2524273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2544806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2568584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2594068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2846743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2950524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-2957697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-3132709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-3138516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-3259205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-6266278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094708-6825182
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8094708-Animals,
pubmed-meshheading:8094708-Blotting, Western,
pubmed-meshheading:8094708-Chaperonin 60,
pubmed-meshheading:8094708-Female,
pubmed-meshheading:8094708-Genes,
pubmed-meshheading:8094708-Heat-Shock Proteins,
pubmed-meshheading:8094708-Listeriosis,
pubmed-meshheading:8094708-Mice,
pubmed-meshheading:8094708-Mice, Inbred BALB C,
pubmed-meshheading:8094708-Mice, Inbred C3H,
pubmed-meshheading:8094708-Polymerase Chain Reaction,
pubmed-meshheading:8094708-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8094708-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:8094708-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Characterization of T-cell receptor gamma delta T cells appearing at the early phase of murine Listeria monocytogenes infection.
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pubmed:affiliation |
Department of Immunology, Kyushu University, Fukuoka.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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