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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1993-3-9
|
| pubmed:abstractText |
The HB24 gene encodes a diverged human homeodomain-containing protein known to be expressed in hematopoietic progenitors and activated lymphocytes. We have generated transgenic mice that express HB24 under the control of the T cell receptor beta chain promoter/enhancer. Analysis of T cells and thymocytes from the transgenic mice revealed a marked increase in activated cells as assessed by cell size profiles and interleukin-2 receptor expression. Within the thymus these changes were most pronounced in the CD4+CD8- subset. Strikingly, the normal development of CD4+ T cells in the transgenic mice was impaired. Single positive CD4 cells were reduced 35% in the thymus, and CD4+ T cells were reduced 90% in the spleen and lymph nodes compared to the controls. Similar findings were found both in young mice (6 weeks old) and in more elderly mice (1 y old). However, the thymuses of the elderly mice failed to undergo normal involution. Sera from HB24 transgenic mice had levels of IgG1 10-100-fold lower than sera from matched controls, most likely as a consequence of the decrease in CD4+ T cells. These transgenic mice provide a useful model for studying the role of HB24 in lymphocyte activation as well as for understanding the effects of abnormal T cell activation on thymic and T cell development.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidyl Peptidase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
268
|
| pubmed:geneSymbol |
HB24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3646-53
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:8094082-Animals,
pubmed-meshheading:8094082-Antibodies,
pubmed-meshheading:8094082-Antigens, CD4,
pubmed-meshheading:8094082-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:8094082-Blotting, Southern,
pubmed-meshheading:8094082-DNA,
pubmed-meshheading:8094082-DNA Probes,
pubmed-meshheading:8094082-Dipeptidyl Peptidase 4,
pubmed-meshheading:8094082-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8094082-Genes, Homeobox,
pubmed-meshheading:8094082-Hematopoietic Stem Cells,
pubmed-meshheading:8094082-Humans,
pubmed-meshheading:8094082-Mice,
pubmed-meshheading:8094082-Mice, Transgenic,
pubmed-meshheading:8094082-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8094082-Reference Values,
pubmed-meshheading:8094082-Restriction Mapping,
pubmed-meshheading:8094082-T-Lymphocyte Subsets,
pubmed-meshheading:8094082-Thymus Gland
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
A human homeobox gene, HB24, inhibits development of CD4+ T cells and impairs thymic involution in transgenic mice.
|
| pubmed:affiliation |
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|