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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-3-3
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pubmed:abstractText |
Polymorphonuclear neutrophils (PMNs) accumulate in postischemic myocardium and may cause injury to myocardium or to vessels by production of oxygen free radicals or by release of proteases and lipases. PMN accumulation is dependent on adherence to endothelium, which is mediated by a family of glycoproteins on the PMN surface, each of which has a common beta-subunit (CD18). The purpose of this study was to determine whether an antibody (IB4) against the CD18 protein could attenuate PMN accumulation and limit myocardial infarct size.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-7322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
526-35
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:8093866-Animals,
pubmed-meshheading:8093866-Antibodies, Monoclonal,
pubmed-meshheading:8093866-Antigens, CD,
pubmed-meshheading:8093866-Antigens, CD18,
pubmed-meshheading:8093866-Cell Cycle,
pubmed-meshheading:8093866-Coronary Circulation,
pubmed-meshheading:8093866-Dogs,
pubmed-meshheading:8093866-Female,
pubmed-meshheading:8093866-Male,
pubmed-meshheading:8093866-Myocardial Infarction,
pubmed-meshheading:8093866-Myocardial Ischemia,
pubmed-meshheading:8093866-Myocardial Reperfusion,
pubmed-meshheading:8093866-Myocardium,
pubmed-meshheading:8093866-Necrosis,
pubmed-meshheading:8093866-Neutrophils,
pubmed-meshheading:8093866-Receptors, Leukocyte-Adhesion,
pubmed-meshheading:8093866-Serum Albumin,
pubmed-meshheading:8093866-Survival Analysis
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pubmed:year |
1993
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pubmed:articleTitle |
Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs.
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pubmed:affiliation |
Department of Pathology, Duke University Medical Center, Durham, N.C. 27710.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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