Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-2-24
pubmed:abstractText
Somatostatin messenger RNA in the antrum and corpus of rat stomach was quantified by Northern and slot blotting using a probe generated by the polymerase chain reaction. Fasting for 48 h enhanced the abundance of somatostatin mRNA in the pyloric antral region, but not in the acid-secreting region of the stomach. In fasted rats, somatostatin mRNA in antrum, but not corpus, was decreased by inhibition of acid secretion with omeprazole. In contrast, in rats treated with capsaicin to lesion small diameter afferents there was a significant decrease in somatostatin mRNA abundance in the corpus but not antrum. The effects of capsaicin cannot be attributed to nonspecific changes in gastric endocrine cell gene expression, since the abundance of histidine decarboxylase mRNA (which is a functionally regulated marker for a different gastric endocrine cell type) did not change with capsaicin. Gastric capsaicin-sensitive afferents are rich in calcitonin gene-related peptide, and in rats with antibodies to this peptide there was reduced corpus somatostatin mRNA. Moreover, infusion of calcitonin gene-related peptide in control rats produced a significant increase in somatostatin mRNA in the gastric corpus. The results indicate that somatostatin mRNA abundance is controlled by the gastric luminal contents and the extrinsic afferent innervation, but the relative importance of these factors differs in antrum and corpus: luminal contents are relatively more important in antrum and primary afferents using calcitonin gene-related peptide in the corpus.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1167869, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1683166, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1692193, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1791979, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1841954, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1910769, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1950793, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1968059, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1968318, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-1976206, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2015894, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2304629, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2412189, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2427663, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2442325, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2455875, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2462184, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2565089, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2580592, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2839796, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2857674, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2867682, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2882688, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2882997, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2897827, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2900791, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-2901431, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-321722, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-3305137, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6084836, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6103859, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6104441, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6133453, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6133871, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6145156, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6145652, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6149697, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093704-6149698
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
244-50
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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